Shrestha, Bijay; Rose, Brennan T.; Olen, Casey L.; Roth, Aaron; Kwong, Adon C.; Wang, Yang; Denmark, Scott E. published the artcile< A Unified Strategy for the Asymmetric Synthesis of Highly Substituted 1,2-Amino Alcohols Leading to Highly Substituted Bisoxazoline Ligands>, Safety of (S)-Methyl 2-hydroxy-3-methylbutanoate, the main research area is amino alc branched asym synthesis acylation heterocyclization; oxazoline bis preparation; sulfinyl imine diastereoselective addition organolithium.
A general procedure for the asym. synthesis of highly substituted 1,2-amino alcs. I (R1 = R2 = Me, Ph; R1 = Me, i-Pr, Ph, R2 = H; R3 = 4-PhC6H4, 2,6-Me2C6H3, 2-pyridyl, etc.) in high yields and diastereoselectivity which uses organometallic additions of a wide range of nucleophiles to tert-butylsulfinimines as the key step is described. The addition of organolithium reagents to these imines follows a modified Davis model. The diastereoselectivity for this reaction depends significantly on both the nucleophile and electrophile. These highly substituted 1,2-amino alcs. were used to synthesize stereochem. diverse and structurally novel, polysubstituted 2,2′-methylene(bisoxazoline) ligands II (R4 = Me, 4-MeOC6H4CH2, 2-naphthylmethyl) in high yields.
Journal of Organic Chemistry published new progress about Amino alcohols, chiral Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 24347-63-5 belongs to class esters-buliding-blocks, and the molecular formula is C6H12O3, Safety of (S)-Methyl 2-hydroxy-3-methylbutanoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics