In 2016,Selvaraju, Manikandan; Ye, Tzuen-Yang; Li, Chia-Hsin; Ho, Pei-Heng; Sun, Chung-Ming published 《Copper catalyzed aerobic oxidative cyclization and ketonization: one pot synthesis of benzoimidazo[1,2-a]imidazolones》.Chemical Communications (Cambridge, United Kingdom) published the findings.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate The information in the text is summarized as follows:
A highly efficient synthesis of benzoimidazo[1,2-a]imidazolone I [R1 = 6-CH3, 6-C(O)OCH3, 7-Cl, etc.; R2 = CH(CH3)2, cyclopentyl, 2-(thiophen-2-yl)ethyl, etc.; R3 = Ph, naphthalen-2-yl, 1-methyl-1H-pyrrol-2-yl, etc.; R4 = 4-H3CC6H4, biphen-4-yl, 2-pyridyl, etc.] through a novel oxidative 5-exo-dig cyclization-ketonization cascade of 2-aminobenzimidazole II [R1 = 5-CH3, 5-C(O)OCH3, 6-Cl, etc.], aldehyde R3CHO and terminal alkyne R4CCH has been explored under aerobic conditions. The reaction proceeds through copper-catalyzed addition of terminal alkynes to imines derived from 2-aminobenzimidazole with aldehyde followed by intramol. cyclization. The atm. mol. oxygen acts as an oxygen source for the newly formed carbonyl group in the final product I. In the experiment, the researchers used Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate)
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoateMethyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics