Application of 1073353-89-5On November 15, 2012 ,《Antileishmanial bis-arylimidamides: DB766 analogs modified in the linker region and bis-arylimidamide structure-activity relationships》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Reid, Carolyn S.; Farahat, Abdelbasset A.; Zhu, Xiaohua; Pandharkar, Trupti; Boykin, David W.; Werbovetz, Karl A.. The article conveys some information:
Analogs of the lead antileishmanial bis-arylimidamide DB766 were prepared that possess unsym. substitutions on the diphenylfuran linker, and an addnl. compound was synthesized that contains isopropoxy groups meta to the central furan. These agents all displayed nanomolar in vitro potency against intracellular Leishmania with selectivity indexes >100 compared to J774 macrophages. While the unsym. analogs were toxic to mice when given i.p. at 30 mg/kg/day, the compound bearing the meta isopropoxy groups was well tolerated by mice and showed activity in a murine model of visceral leishmaniasis when administered i.p. at 30 mg/kg/day for five days.2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1073353-89-5Application of 1073353-89-5) was used in this study.
2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1073353-89-5) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Application of 1073353-89-5 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics