Rachedi, Khadidja Otmane; Ouk, Tan-Sothea; Bahadi, Rania; Bouzina, Abdeslem; Djouad, Seif-Eddine; Bechlem, Khaoula; Zerrouki, Rachida; Ben Hadda, Taibi; Almalki, Faisal; Berredjem, Malika published the artcile< Synthesis, DFT and POM analyses of cytotoxicity activity of α-amidophosphonates derivatives: Identification of potential antiviral O,O-pharmacophore site>, Reference of 2743-40-0, the main research area is acylaminoester preparation phosphorylation ethylphosphite; amidophosphonate preparation anticancer agent optimized geometry DFT; amino acid acylation phosphorylation reaction.
The authors studied the cytotoxic activity of three compounds prepared starting from amino acids. These derivatives were evaluated for their in vitro antitumor activity against human cell lines (PRI, K562 and JURKAT). Their cytotoxicity was also evaluated at different concentrations on several cell lines. However, DFT calculation was used to analyze the electronic and geometric characteristics. The HOMO, LUMO and gap energies were also deduced for the stable structure for each compound These results will be correlated with the exptl. values. The bioinformatic POM (Petra/Osiris/Molinspiration) analyses of the relative cytotoxicity of these derivatives are reported in comparison to Chlorambucil.
Journal of Molecular Structure published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Reference of 2743-40-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics