Formula: C5H11NO3In 2019 ,《Traceless Templated Amide-Forming Ligations》 was published in Journal of the American Chemical Society. The article was written by Osuna Galvez, Alberto; Bode, Jeffrey W.. The article contains the following contents:
Template assistance allows organic reactions to occur under highly dilute conditions-where intermol. reactions often fail to proceed-by bringing reactants into close spatial proximity. This strategy has been elegantly applied to numerous systems, but always with the retention of at least one of the templating groups in the product. In this report, the authors describe a traceless, templated amide-forming ligation that proceeds at low micromolar concentration under aqueous conditions in the presence of biomols. The authors utilized the unique features of an acylboronate-hydroxylamine ligation, in which covalent bonds are broken in each of the reactants as the new amide bond is formed. By using streptavidin as a template and acylboronates and O-acylhydroxylamines bearing desthiobiotins that are cleaved upon amide formation, the authors demonstrate that traceless, templated ligation occurs rapidly even at submicromolar concentrations The requirement for a close spatial orientation of the functional groups-achieved upon binding to streptavidin-is critical for the observed enhancement in the rate and quantity of product formed. The experimental process involved the reaction of N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Formula: C5H11NO3)
N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Formula: C5H11NO3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics