The author of 《Biosensing with Insect Odorant Receptor Nanodiscs and Carbon Nanotube Field-Effect Transistors》 were Murugathas, Thanihaichelvan; Zheng, Han Yue; Colbert, Damon; Kralicek, Andrew V.; Carraher, Colm; Plank, Natalie O. V.. And the article was published in ACS Applied Materials & Interfaces in 2019. Synthetic Route of C8H8O3 The author mentioned the following in the article:
Insect odorant receptors have been reconstituted into lipid nanodiscs and tethered to carbon nanotube field-effect transistors to function as a biosensor. Here, four different insect odorant receptors (ORs) from Drosophila melanogaster (DmelOR10a, DmelOR22a, DmelOR35a, and DmelOR71a) were expressed in Sf9 cells, purified, and reconstituted into lipid nanodiscs. We have demonstrated that each of these ORs produce a selective and highly sensitive elec. response to their resp. pos. ligands, Me salicylate, Me hexanoate, trans-2-hexen-1-al, and 4-ethylguaiacol, with limits of detection in the low femtomolar range. No detection was observed for each OR against control ligands, and empty nanodiscs showed no specific sensor signal for any of the odorant mols. Our results are the first evidence that insect ORs can be integrated into lipid nanodiscs and used as primary sensing elements for bioelectronic nose technologies. In the experiment, the researchers used Methyl Salicylate(cas: 119-36-8Synthetic Route of C8H8O3)
Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Synthetic Route of C8H8O3
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