Morita, Iwao; Haruta, Yuko; Tomita, Toshio; Tsuda, Masami; Kandori, Kazuhisa; Kise, Masahiro; Kimura, Kiyoshi published the artcile< Syntheses and antihypertensive activities of 1,4-dihydropyridine-5-phosphonate derivatives. III>, COA of Formula: C7H12O5, the main research area is cyclocondensation arylideneacetonylphosphonate aminocrotonate; hydropyridinephosphonate preparation antihypertensive activity; pyridinephosphonate phenyldihydro preparation antihypertensive activity.
Phenyldihydropyridinephosphonates I [RR = (CH2)3, CH2CMe2CH2; R = CO2Me, allyl; R1 = 2-NO2, 2-CF3, 2-OCHF2, 3-NO2; R2 = Me, CH2CHMe2, CH2CH2OCH2Ph, CH2CH2OMe, CH2CH2NMeCH2Ph, allyl; R3 = Me, Et, Pr, allyl, CH2Ph, CH2CH2OMe, NMe2; R4 = Me] were prepared by the cyclocondensation reaction of R3NHCMe:CHCO2R2 with R1C6H4CH:CAcP(O)(OR)2 (II). I [R = allyl, RR = (CH2)3; R1 = 2-NO2, 3-NO2, 2-CF3; R2 = Me; R3 = H; R4 = CH(OMe)2] were prepared similarly by the reaction of II with (MeO)2CHC(NH2):CHCO2Me. I [R4 = CH(OMe)2] was deprotected to give I (same R-R3; R4 = CHO). The latter were converted to I (R4 = CH2OH, CH:NOH, cyano). I were all tested for antihypertensive activity in normotensive and spontaneously hypertensive rats. I [RR = (CH2)3, R1 = 2-NO2, R2 = Me, R3 = R4 = Me] shows higher antihypertensive activity than nifedipine, but lower than DHP-218.
Chemical & Pharmaceutical Bulletin published new progress about Antihypertensives. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, COA of Formula: C7H12O5.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics