Safety of Ethyl 3-oxopentanoateIn 2019 ,《Investigation of biaryl heterocycles as inhibitors of Wee1 kinase》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Mastracchio, Anthony; Lai, Chunqiu; Torrent, Maricel; Bromberg, Kenneth; Buchanan, Fritz G.; Ferguson, Debra; Bontcheva, Velitchka; Johnson, Eric F.; Lasko, Loren; Maag, David; Soni, Nirupama; Shoemaker, Alexander R.; Penning, Thomas D.. The article conveys some information:
In continuation of our previous research towards the discovery of potent, selective and drug-like Wee1 inhibitors, 2 novel series of biaryl heterocycles were designed, synthesized and evaluated. The new biaryl cores were designed to enable structure-activity exploration of substituents at C-8 or N-8 which were used for tuning compound properties and to improve compound profiles. The lead mol. I demonstrated a desirable pharmacokinetic profile and potentiated the anti-proliferative activity of irinotecan in vivo when dosed orally in the human breast MX-1 xenograft model. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-oxopentanoate(cas: 4949-44-4Safety of Ethyl 3-oxopentanoate)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Safety of Ethyl 3-oxopentanoate
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