Ma, Qihong; Dong, Shi; Shi, Yuanyuan; Lu, Tiangong published the artcile< Guizhi-Fuling formula inhibits ovarian cancer progression by targeting STAT3 signaling network>, Formula: C19H34O2, the main research area is guizhi fuling formula ovarian cancer progression STAT3 signal transduction.
Ovarian cancer (OC) is the most lethal gynecol. malignancy. Frequent peritoneal dissemination is the main cause of low survival rate. Guizhi-Fuling formula (GZFL) is a classical traditional Chinese herbal formula, and has been clin. used for treating ovarian cancer with good outcome. However, its therapeutic mechanism for treating OC has not been clearly elucidated. Network pharmacol. anal. was used to predict potential mol. mechanisms of GZFL in treating OC. In vitro and in vivo anal., including STAT3 KO/WT cells proliferation assay, scratch assay and antitumor efficacy study were performed to assess the biol. activity of GZFL on targeting STAT3 in OC cells. We generated a “”GZFL target – OC – STAT3″” gene interaction network, and predicted that GZFL is tightly associated with IL6/JAK/STAT3 signal pathway and cancer metastasis. Our preliminary data showed that GZFL inhibited OC cell proliferation in a STAT3 dependent manner. It suppressed cell migration and downregulated p-STAT3 expression. In a tumor bearing mouse model, GZFL displayed a safety profile. GZFL inhibits OC progression by targeting STAT3 signaling network. Our newly proposed pharmacol. mechanisms of Guizhi-Fuling formula will provide a new insight for its clin. use in treating OC.
TMR Modern Herbal Medicine published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.
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