Liu, Lei; Lee, Wes; Youshaw, Cassandra R.; Yuan, Mingbin; Geherty, Michael B.; Zavalij, Peter Y.; Gutierrez, Osvaldo published the artcile< Fe-catalyzed three-component dicarbofunctionalization of unactivated alkenes with alkyl halides and Grignard reagents>, Category: esters-buliding-blocks, the main research area is alkylarylated compound chemoselective regioselective diastereoselective preparation; alkene alkylhalide Grignard reagent three component dicarbofunctionalization iron catalyst.
A highly chemoselective iron-catalyzed three-component dicarbofunctionalization of unactivated olefins with alkyl halides (iodides and bromides) and sp2-hybridized Grignard reagents was reported. The reaction operates under fast turnover frequency and tolerated a diverse range of sp2-hybridized nucleophiles, alkyl halides and unactivated olefins to yield the desired 1,2-alkylarylated products R1R2R3CCH2CHRCH2alkyl [R = Ph, 4-MePH, 2-naphthyl, etc.; R1 = H, Me; R2 = H, Me, Et; R3 = Me, Et, (CH2)2Ph, etc.; alkyl = n-hexyl, (CH2)2CH:CH, (CH2)2Ph, etc.] with high regiocontrol. Further, this protocol was amenable for the synthesis of new (hetero)carbocycles including tetrahydrofurans and pyrrolidines such as I [Ar = 3-MeOPh, 2-MePH, 3-thienyl, etc.; X = O] via a three-component radical cascade cyclization/arylation that forges three new C-C bonds was also demonstrated.
Chemical Science published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics