Li, Ying; Belt, Katharina; Alqahtani, Saad F.; Saha, Saurabh; Fenske, Ricarda; Van Aken, Olivier; Whelan, James; Millar, A. Harvey; Murcha, Monika W.; Huang, Shaobai published the artcile< The mitochondrial LYR protein SDHAF1 is required for succinate dehydrogenase activity in Arabidopsis>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Arabidopsis mitochondrial LYR protein succinate dehydrogenase activity; assembly factors; complex II; iron-sulfur cluster insertion; mitochondrial metabolism; succinate dehydrogenase.
Succinate dehydrogenase (SDH, complex II), which plays an essential role in mitochondrial respiration and tricarboxylic acid metabolism, requires the assembly of eight nuclear-encoded subunits and the insertion of various cofactors. Here, we report on the characterization of an Arabidopsis thaliana leucine-tyrosine-arginine (LYR) protein family member SDHAF1, (At2g39725) is a factor required for SDH activity. SDHAF1 is located in mitochondria and can fully complement the yeast SDHAF1 deletion strain. Knockdown of SDHAF1 using RNA interference resulted in a decrease in seedling hypocotyl elongation and reduced SDH activity. Proteomic analyses revealed a decreased abundance of various SDH subunits and assembly factors. Protein interaction assays revealed that SDHAF1 can interact exclusively with the Fe-S cluster-containing subunit SDH2 and HSCB, a cochaperone involved in Fe-S cluster complex recruitment. Therefore, we propose that in Arabidopsis, SDHAF1 plays a role in the biogenesis of SDH2 to form the functional complex II, which is essential for mitochondrial respiration and metabolism
Plant Journal published new progress about Arabidopsis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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