In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Kunkalkar, Rupesh A.; Fernandes, Rodney A.. Electric Literature of C5H6O2. The article was titled 《Lewis acid-catalyzed annulative partial dimerization of 3-aryloxyacrylates to 4-arylchroman-2-ones: synthesis of analogues of tolterodine, RORγ inhibitors and a GPR40 agonist》. The information in the text is summarized as follows:
A beguiling annulative partial dimerization of 3-aryloxyacrylates to 4-arylchroman-2-ones e.g. I catalyzed by Lewis acid (BF3·OEt2) has been developed. The reaction involves two mols. of 3-aryloxyacrylate, resulting in the loss of one propiolate mol. to furnish 4-arylchroman-2-one, an important structural motif found in many natural products. This methodol. has been elaborated to synthesize analogs of tolterodine, RORγ inhibitors and a GPR40 agonist.Ethyl propiolate(cas: 623-47-2Electric Literature of C5H6O2) was used in this study.
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Electric Literature of C5H6O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics