Kizhakkayil Mangadan, Arun Raj; Liu, Ji; Aponick, Aaron published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Enantioselective Lactonization by π-Acid-Catalyzed Allylic Substitution: A Complement to π-Allylmetal Chemistry》.Name: Ethyl 2-methyl-3-oxobutanoate The article contains the following contents:
Asym. allylic alkylation (AAA) is a powerful method for the formation of highly useful, non-racemic allylic compounds A complementary enantioselective process that generates allylic lactones via π-acid catalysis was presented. More specifically, a catalytic enantioselective dehydrative lactonization of allylic alcs. using a novel PdII-catalyst containing the imidazole-based P,N-ligand (S)-StackPhos is reported. The high-yielding reactions are operationally simple to perform with enantioselectivities up to 99% ee. This strategy facilitates the replacement of a poor leaving group with what would ostensibly be a better leaving group in the product avoiding complications arising from racemization by equilibration. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Name: Ethyl 2-methyl-3-oxobutanoate)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Name: Ethyl 2-methyl-3-oxobutanoate
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