HPLC of Formula: 2495-35-4In 2019 ,《Rhodium(III)-catalyzed regioselective distal ortho C-H alkenylation of N-benzyl/furanylmethylpyrazoles directed by N-coordinating heterocycles》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Kim, Hyewon; Thombal, Raju S.; Khanal, Hari Datta; Lee, Yong Rok. The article conveys some information:
C-H activation of challenging N-benzylpyrazoles I (R = H, Me, Br, Cl; R1 = H, Me, Br, 4-fluorophenyl, etc.; R2 = H; R3 = H, Br, Cl, Me, etc.; R2R3, RR2= -CH=CH-CH=CH-) using acrylates CH2=CHC(O)OR4 (R4 = Me, Ph, Bn, etc.) was accomplished by employing rhodium(III) catalysis. This C-H activation reaction proceeds via a six-membered rhodacycle intermediate and enables distal regioselective alkenyl-functionalization on the aromatic ring of N-benzylpyrazoles II without the formation of bis-adducts. High functional group tolerance, low catalyst loading, and superior reactivity of olefin moieties towards N-benzylpyrazoles I are some of the attractive features of this protocol. This protocol offers a broad scope for the regioselective functionalization of indazoles III and IV, benzo[d][1,2,3]triazoles V, and 1-(furan-3-ylmethyl)-1H-pyrazole in good yields.Benzyl acrylate(cas: 2495-35-4HPLC of Formula: 2495-35-4) was used in this study.
Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.HPLC of Formula: 2495-35-4
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