Hao, Lin; Chuen, Chan Wei; Ganguly, Rakesh; Chi, Yonggui Robin published the artcile< NHC-catalyzed ester activation: access to sterically congested spirocyclic oxindoles via reaction of α-aryl esters and unsaturated imines>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is spirocyclic oxindole preparation; aryl ester imine heterocyclic carbene.
Carboxylic esters can be readily obtained at low cost. Therefore, asym. catalytic activation of esters should provide useful strategies for organic synthesis. Here we report a N-heterocyclic carbene (NHC)-mediated reaction of α-aryl acetic esters with oxindole-derived α,β-unsaturated imines. The reaction involves the formation of NHC-bound ester enolate intermediate from an ester as a key step, and furnishes spirocyclic oxindole products. The sterically congested spirocyclic oxindole e. g., I, bears a newly formed six-membered δ-lactams and cannot be easily prepared using other methods.
Synlett published new progress about Aromatic esters Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics