In 2022,Feng, Minghao; Madegard, Lea; Riomet, Margaux; Louis, Manon; Champagne, Pier Alexandre; Pieters, Gregory; Audisio, Davide; Taran, Frederic published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Selective chlorination of iminosydnones for fast release of amide, sulfonamide and urea-containing drugs》.Computed Properties of C5H11NO2 The author mentioned the following in the article:
Herein, a methodol. for iminosydnone chlorination is described, and the high beneficial effect of this modification on the reactivity of these mesoionic dipoles in strain-promoted cycloaddition reactions is demonstrated. These new iminosydnones were used in reactions with azacyclooctyne for bioorthogonal release of amide, urea and sulfonamide containing drugs. Notably, drugs containing a terminal amide function were released for the first time with good kinetic constants In addition to this study using tert-Butyl carbamate, there are many other studies that have used tert-Butyl carbamate(cas: 4248-19-5Computed Properties of C5H11NO2) was used in this study.
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Computed Properties of C5H11NO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics