Desai, Asim H.; Patil, Sanjay N.; Patel, Mehul K.; Jain, Anandkumar B.; Desai, Jignasu T.; Choubey, Ajit Kumar published an article in 2021. The article was titled 《Development of purification process of edoxaban intermediate (ethyl-2- [(5-chloropyridine-2-Yl)amino]-2-oxoacetate hydrochloride)》, and you may find the article in Journal of Applicable Chemistry (Lumami, India).Application of 4755-77-5 The information in the text is summarized as follows:
Purification method for preparation of edoxaban intermediate, i.e., ethyl-2-[(5-chloropyridine-2- yl)amino]-2-oxoacetate hydrochloride formula using the alc. solvent at reflux condition was reported. The purity of edoxaban intermediate was increased by implementing these manufacturing processes. The process provided in the present invention involved convenient operations and high purity efficiency (<99%). The process was environmental-friendly and suitable for com. scale. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Application of 4755-77-5)
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application of 4755-77-5
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