《Synthesis and hetero-Diels-Alder reactions of enantiomerically pure dihydro-1H-azepines》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Craig, Donald; Spreadbury, Samuel R. J.; White, Andrew J. P.. Safety of N-tert-Butoxycarbonylhydroxylamine The article mentions the following:
Thermolysis of enantiomerically pure 3-substituted 7,7-dihalo-2-azabicyclo[4.1.0]heptanes (1R,3S,6S/1S,3S,6R/(1R,3R,6S)(S)/(1S,3R,6R)(S))-I [X = Cl, Br; R = Me, Bn, 2-[(tert-butyldiphenylsilyl)oxy]ethyl, etc.] in the presence of K2CO3 results in good yields of 2-alkyl-6-halo-1-tosyl-2,3-dihydro-1H-azepines (R/S/(R)(S))-II. These compounds undergo highly stereoselective [4+2] cycloaddition reactions with heterodienophiles such as 4-phenyl-3H-1,2,4-triazole-3,5(4H)-dione, tert-Bu hydroxycarbamate, benzyl hydroxycarbamate and arylation/alkenylation under Suzuki conditions. After reading the article, we found that the author used N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3Safety of N-tert-Butoxycarbonylhydroxylamine)
N-tert-Butoxycarbonylhydroxylamine(cas: 36016-38-3) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Safety of N-tert-Butoxycarbonylhydroxylamine
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