Ceglowski, Michal; Kurczewska, Joanna; Ruszkowski, Piotr; Liberska, Joanna; Schroeder, Grzegorz published the artcile< The influence of crosslinking agent onto adsorption properties, release behavior and cytotoxicity of doxorubicin-imprinted microparticles>, Formula: C18H26O6, the main research area is doxorubicin molecularly imprinted polymer microparticle crosslinking agent adsorption release; Cell culture; Doxorubicin; Drug delivery; Microspheres; Molecularly imprinted polymers.
Molecularly imprinted polymers (MIPs) are synthetic polymers that possess cavities selective towards their mol. templates and have found many applications in separation science, drug delivery, and catalysis. Here, we report the synthesis of doxorubicin-imprinted microparticles crosslinked with two different compounds (ethylene glycol dimethacrylate or trimethylolpropane trimethacrylate) and examination of their physicochem. properties. During the synthesis methacrylic acid was used as functional monomer and 2-hydroxyethyl methacrylate was added into polymerization mixture to increase hydrophilicity of the obtained materials and therefore improve interactions with aqueous release medium. The influence of initial concentration and contact time onto doxorubicin adsorption by obtained MIPs microparticles have been investigated. The microparticles obtained using ethylene glycol dimethacrylate as a crosslinker showed 3 times higher adsorption properties towards doxorubicin, than the ones obtained using trimethylolpropane trimethacrylate crosslinker. The release kinetics of doxorubicin from drug-loaded MIPs microparticles has been proven to be dependent upon crosslinker used and pH of the release medium. For drug-loaded MIPs microparticles obtained using both crosslinkers the IC50 values measured for cancer cell were comparable to the ones measured for pure doxorubicin, whereas the cytotoxicity towards normal HDF cell lines was lower.
Colloids and Surfaces, B: Biointerfaces published new progress about Adsorption. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Formula: C18H26O6.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics