In 2004,Andrews, Stephen P.; Joensson, Daniel; Warrington, Brian H.; Ladlow, Mark published 《Automated parallel, multi-step polymer-assisted solution phase (PASP) synthesis of substituted benzimidazole derivatives》.Combinatorial Chemistry and High Throughput Screening published the findings.Reference of Methyl 4-fluoro-3-nitrobenzoate The information in the text is summarized as follows:
The automated polymer-assisted solution phase (PASP) synthesis of a 72 member library of 1-R1-2-R2S-5-R3C(O)benzimidazoles (e.g. 2-(benzylthio)-1-sec-butyl-5-(cyclopentylcarbamoyl)benzimidazole) and 1-R1-3-R2-5-R3C(O)benzimidazol-2(3H)-ones (e.g. 3-benzyl-1-sec-butyl-5-(cyclopentylcarbamoyl)-1H-benzimidazol-2(3H)-one) using com. available robotic workstations is described. By incorporating both automated aqueous work-ups, in-line scavenging and catch and release protocols the desired compounds were obtained directly in good yields and excellent purities without the need for conventional chromatog. purification The synthesis described demonstrates how both manual and automated equipment may be used together to provide a versatile approach that facilitates parallel compound synthesis. In addition to this study using Methyl 4-fluoro-3-nitrobenzoate, there are many other studies that have used Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Reference of Methyl 4-fluoro-3-nitrobenzoate) was used in this study.
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Reference of Methyl 4-fluoro-3-nitrobenzoateMethyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.
Referemce:
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