Adusumalli, Srinivasa Rao; Rawale, Dattatraya Gautam; Thakur, Kalyani; Purushottam, Landa; Reddy, Neelesh C.; Kalra, Neetu; Shukla, Sanjeev; Rai, Vishal published an article in Angewandte Chemie, International Edition. The title of the article was 《Chemoselective and Site-Selective Lysine-Directed Lysine Modification Enables Single-Site Labeling of Native Proteins》.COA of Formula: C13H16O5 The author mentioned the following in the article:
The necessity for precision labeling of proteins emerged during the efforts to understand and regulate their structure and function. It demands selective attachment of tags such as affinity probes, fluorophores, and potent cytotoxins. Here, the authors report a method that enables single-site labeling of a high-frequency Lys residue in the native proteins. At first, the enabling reagent forms stabilized imines with multiple solvent-accessible Lys residues chemoselectively. These linchpins create the opportunity to regulate the position of a second Lys-selective electrophile connected by a spacer. Consequently, it enables the irreversible single-site labeling of a Lys residue independent of its place in the reactivity order. The user-friendly protocol involves a series of steps to deconvolute and address chemoselectivity, site-selectivity, and modularity. Also, it delivers ordered immobilization and anal. pure probe-tagged proteins. Besides, the methodol. provides access to antibody-drug conjugate (ADC), which exhibits highly selective anti-proliferative activity towards HER-2 expressing SKBR-3 breast cancer cells. After reading the article, we found that the author used Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8COA of Formula: C13H16O5)
Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters.COA of Formula: C13H16O5 They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics