Zhang, Youchi; Zhang, Jingli; Yuan, Ye; Liu, Liran; Chen, Bifeng; Sun, Taolei published the artcile< Synthesis of Polysubstituted 2H-Pyran-2-ones or Phenols via One-Pot Reaction of (E)-β-Chlorovinyl Ketones and Electron-Withdrawing Group Substituted Acetates or β-Diketones>, COA of Formula: C11H12O3, the main research area is pyranone polysubstituted phenol preparation chlorovinyl ketone acetate beta diketone.
This paper describes a facile one-pot synthesis of highly functionalized 2H-pyran-2-ones and phenols through a base-promoted annulation of readily available β-chlorovinyl ketones with various active methylene compounds Conjugate addition of electron-withdrawing group substituted acetates to allenone intermediates and direct conjugate addition of β-diketones to β-chlorovinyl ketones reveal versatile electrophilic pathways of β-chlorovinyl ketones under different reaction conditions. In particular, cyclocondensation is regiospecific for 3,5-disubstituted phenols. Moreover, the utility of [3+3] cyclocondensation is further illustrated by the concise synthesis of benzofuran derivative and penta- or hexa-substituted phenol construction.
European Journal of Organic Chemistry published new progress about Active methylene compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, COA of Formula: C11H12O3.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics