Zhang, Xi; Liu, Dong-yun; Shang, Hai; Jia, Yi; Xu, Xu-Dong; Tian, Yu; Guo, Peng published the artcile< Amino acid ester-coupled caffeoylquinic acid derivatives as potential hypolipidemic agents: synthesis and biological evaluation>, Recommanded Product: H-Leu-OEt.HCl, the main research area is amino acid ester coupled caffeoylquinic derivative hypolipidemic agent.
Pandanus tectorius (L.) Parkins.(PTPs) is rich in caffeoylquinic acids and amino acids, especially some essential amino acids, such as valine, phenylalanine, and so forth. A series of novel amino acid ester-coupled caffeoylquinic acid derivatives have been designed and synthesized. Biol. evaluation suggested that some amino acid ester-coupled derivatives exhibited varying degrees of lipid-lowering effects on oleic acid-elicited lipid accumulation in HepG2 liver cells. Particularly, derivatives 6c, 6d, 6e and 6f exhibited comparable potential lipid-lowering effect with the pos. control simvastatin and chlorogenic acid. Further studies on the mechanism of 6c, 6d, 6e and 6f revealed that the lipid-lowering effects were related to their regulation of TG levels and mRNA levels of lipometabolic-modulating genes, and merit further investigation.
RSC Advances published new progress about Amino acid esters Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Recommanded Product: H-Leu-OEt.HCl.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics