Wang, Xiaoyu; Wan, Meiyin; Zhang, Lei; Dai, Yongdong; Hai, Yang; Yue, Chenda; Xu, Junqi; Ding, Yadan; Wang, Mei; Xie, Jianping; Lei, Xia; Zhong, Julia-Li published the artcile< ALA_PDT Promotes Ferroptosis-Like Death of Mycobacterium abscessus and Antibiotic Sterilization via Oxidative Stress>, Category: esters-buliding-blocks, the main research area is Mycobacterium abscessus 5aminolevulinic acid photodynamic therapy oxidative tress; ferroptosis antibiotic; ALA_PDT; Mycobacterium abscessus; antibiotic resistance; ferroptosis; heme oxygenase MAB_4773.
Mycobacterium abscessus is one of the common clin. non-tuberculous mycobacteria (NTM) that can cause severe skin infection. 5-Aminolevulinic acid photodynamic therapy (ALA_PDT) is an emerging effective antimicrobial treatment. To explore whether ALA_PDT can be used to treat M. abscessus infections, we conducted a series of experiments in vitro. We found that ALA_PDT can kill M. abscesses. Mechanistically, we found that ALA_PDT promoted ferroptosis-like death of M. abscesses, and the ROS scavenger N-Acetyl-L-cysteine (NAC) and ferroptosis inhibitor Ferrostatin-1 (Fer-1) can mitigate the ALA_PDT-mediated sterilization. Furthermore, ALA_PDT significantly up-regulated the transcription of heme oxygenase MAB_4773, increased the intracellular Fe2+ concentration and altered the transcription of M. abscessus iron metabolism genes. ALA_PDT disrupted the integrity of the cell membrane and enhanced the permeability of the cell membrane, as evidenced by the boosted sterilization effect of antibiotics. In summary, ALA_PDT can kill M. abscesses via promoting the ferroptosis-like death and antibiotic sterilization through oxidative stress by changing iron metabolism The study provided new mechanistic insights into the clin. efficacy of ALA_PDT against M. abscessus.
Antioxidants published new progress about Antibiotics. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Category: esters-buliding-blocks.
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Ester – an overview | ScienceDirect Topics