Wang, Lan; Zhang, Yuhuan; Han, Ying; Zhang, Qi; Wen, Zhenfu; Li, Hongjuan; Sun, Shiguo; Chen, Xin; Xu, Yongqian published an article in 2021. The article was titled 《Nanoscale photosensitizer with tumor-selective turn-on fluorescence and activatable photodynamic therapy treatment for COX-2 overexpressed cancer cells》, and you may find the article in Journal of Materials Chemistry B: Materials for Biology and Medicine.SDS of cas: 51857-17-1 The information in the text is summarized as follows:
Effective targeting and in situ imaging-guided treatment are particularly important for accurate clin. photodynamic therapy (PDT) of malignant tumors. Herein, we propose a single mol., named IMC-DAH-SQ, which possesses dual-targeting components, including structure-inherent targeting (SIT) and cyclooxygenase-2 (COX-2) targeting units, and controllable turn-on near IR (NIR) fluorescence. Due to its amphiphilicity, IMC-DAH-SQ assembles into a nanoprobe with low background fluorescence. After incubation with tumor cells, the SIT and COX-2 recognition characteristics of IMC-DAH-SQ endow it with preferential tumor-targeting activity. The strong binding with overexpressed COX-2 can collapse the nanoprobe to monomers after accumulation in tumor cells, leading to turn-on NIR fluorescence that is completely different from normal cells. Addnl., benefiting from the single mol. model tactic, the nanoprobe has the advantages of simple synthesis without ever considering the loading rate and separation between the photosensitizer and targeting unit. Other favorite features, including superior biocompatibility, weak dark toxicity, and mitochondria enrichment capability, are implemented. All these traits not only afford nanoprobe precision tumor cell targeting capability but also provide promising imaging-guided antitumor therapy. We believe that the single mol. protocol will establish a novel strategy for simultaneous diagnosis and anticancer medicine treatment utilizing versatile but small compounds In the experimental materials used by the author, we found N-Boc-1,6-Diaminohexane(cas: 51857-17-1SDS of cas: 51857-17-1)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsSDS of cas: 51857-17-1
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