Venugopala, Katharigatta N.; Chandrashekharappa, Sandeep; Deb, Pran Kishore; Tratrat, Christophe; Pillay, Melendhran; Chopra, Deepak; Al-Shar’i, Nizar A.; Hourani, Wafa; Dahabiyeh, Lina A.; Borah, Pobitra; Nagdeve, Rahul D.; Nayak, Susanta K.; Padmashali, Basavaraj; Morsy, Mohamed A.; Aldhubiab, Bandar E.; Attimarad, Mahesh; Nair, Anroop B.; Sreeharsha, Nagaraja; Haroun, Michelyne; Shashikanth, Sheena; Mohanlall, Viresh; Mailavaram, Raghuprasad published an article in 2021. The article was titled 《Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme》, and you may find the article in Journal of Enzyme Inhibition and Medicinal Chemistry.Safety of Ethyl propiolate The information in the text is summarized as follows:
A series of 1,2,3-trisubstituted indolizines (, and ) were screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compounds , , and were active against the H37Rv-MTB strain with min. inhibitory concentration (MIC) ranging from 4 to 32μg/mL, whereas the indolizines with Et ester group at the 4-position of the benzoyl ring also exhibited anti-MDR-MTB activity (MIC = 16-64μg/mL). In silico docking study revealed the enoyl-acyl carrier protein reductase (InhA) and anthranilate phosphoribosyltransferase as potential mol. targets for the indolizines. The X-ray diffraction anal. of the compound was also carried out. Further, a safety study (in silico and in vitro) demonstrated no toxicity for these compounds Thus, the indolizines warrant further development and may represent a novel promising class of InhA inhibitors and multi-targeting agents to combat drug-sensitive and drug-resistant MTB strains. In the experiment, the researchers used many compounds, for example, Ethyl propiolate(cas: 623-47-2Safety of Ethyl propiolate)
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Safety of Ethyl propiolate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics