Sun, Li; Cui, Jean; Liang, Congxin; Zhou, Yong; Nematalla, Asaad; Wang, Xueyan; Chen, Hui; Tang, Cho; Wei, James published the artcile< Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185erbB) tyrosine kinases>, Name: Ethyl 5-formyl-1H-pyrrole-2-carboxylate, the main research area is dihydropyrimidine derivative preparation EGF receptor Her2 tyrosine kinase inhibitor; structure activity dihydropyrimidine derivative preparation EGFR Her2 tyrosine kinase.
A novel class of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones has been discovered as potent and selective inhibitors of the EGF-R tyrosine kinase family. These compounds selectively inhibit EGF-R kinase activity at low nanomolar concentration and tyrosine autophosphorylation in cells expressing EGF-R or Her2 (p185erbB). Structure-activity relationships (SARs) for this class of compounds are presented.
Bioorganic & Medicinal Chemistry Letters published new progress about Drug design. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Name: Ethyl 5-formyl-1H-pyrrole-2-carboxylate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics