Shi, Chang-Xia; Guo, Yu-Ting; Wu, Yu-Huan; Li, Zhao-Yue; Wang, Yao-Zong; Du, Fu-Sheng; Li, Zi-Chen published the artcile< Synthesis and Controlled Organobase-Catalyzed Ring-Opening Polymerization of Morpholine-2,5-Dione Derivatives and Monomer Recovery by Acid-Catalyzed Degradation of the Polymers>, HPLC of Formula: 2743-40-0, the main research area is acid catalyzed degradation polymer morpholine dione ring opening polymerization.
Polydepsipeptides (PDPs) are strictly alternating copolymers of α-hydroxy acids and α-amino acids produced via the ring-opening polymerization (ROP) of morpholino-2,5-dione derivatives (MDs). They have been used as promising biomaterials for their combined high thermal stability and good mech. properties of polyamides as well as the inherent degradability of polyesters. ROP of MDs is usually carried out at high temperatures with metal catalysts or enzymes, with less control over the polymer mol. weights and dispersities. In this work, we developed a simple and efficient synthetic strategy of a new platform MD via the Passerini-type reaction between an isocyano derivative of the amino acid and an aldehyde, followed by intramol. esterification. Nine new MDs were synthesized by using this method, and the organobase-catalyzed ROP of these MDs was investigated. When the ROPs of these MDs were catalyzed by either triazabicyclo[4.4.0]dec-5-ene (TBD) or diazabicyclo[5.4.0]undec-7-ene (DBU) in the presence of benzyl alc. as an initiator, the polymerizations were uncontrolled with the formation of both linear PDPs and cyclic PDPs. By using binary catalytic systems of 1-(3,5-bis(trifluoromethyl)-phenyl-3-cyclohexyl-2-thiourea) (TU) with DBU or TBD ([TU]/[TBD] or [DBU] > 3), the polymerizations became well-controlled, allowing the synthesis of PDPs with controlled mol. weights, low dispersities, as well as block copolymers. Furthermore, cyclic PDPs were obtained when the ROP of these MDs was catalyzed with TBD in the absence of both TU and an initiator. Finally, we used two methods to recover the monomer precursors or pure MD monomers: the TBD-catalyzed alcoholysis of PDPs was very fast and generated the monomer precursors quant., while the acid-catalyzed depolymerization of PDPs led to pure and quant. monomer recovery.
Macromolecules (Washington, DC, United States) published new progress about Crystal structure. 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, HPLC of Formula: 2743-40-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics