Rajendran, Abinaya; Soory, Amarendranath; Khandelwal, Neha; Ratnaparkhi, Girish; Kamat, Siddhesh S. published the artcile< A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals>, Product Details of C19H34O2, the main research area is lysine deacetylase ABHD14B post translational modification glucose metabolism; ABHD14B; glucose metabolism; lysine deacetylase; metabolomics; transcriptomics.
The sirtuins and histone deacetylases are the best characterized members of the lysine deacetylase (KDAC) enzyme family. Recently, we annotated the orphan enzyme ABHD14B (α/β-hydrolase domain containing protein 14B) as a novel KDAC and showed this enzyme’s ability to transfer an acetyl-group from protein lysine residue(s) to coenzyme-A to yield acetyl-coenzyme-A, thereby, expanding the repertoire of this enzyme family. However, the role of ABHD14B in metabolic processes is not fully elucidated. Here, we investigated the role of this enzyme using mammalian cell knockdowns in a combined transcriptomics and metabolomics anal. We found from these complementary experiments in vivo that the loss of ABHD14B results in significantly altered glucose metabolism, specifically the decreased flux of glucose through glycolysis and the citric acid cycle. Further, we show that depleting hepatic ABHD14B in mice also results in defective systemic glucose metabolism, particularly during fasting. Taken together, our findings illuminate the important metabolic functions that the KDAC ABHD14B plays in mammalian physiol. and poses new questions regarding the role of this hitherto cryptic metabolism-regulating enzyme.
Journal of Biological Chemistry published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (ABHD14B). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.
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