Oishi, Shinya; Watanabe, Toshiaki; Sawada, Jun-ichi; Asai, Akira; Ohno, Hiroaki; Fujii, Nobutaka published the artcile< Kinesin Spindle Protein (KSP) Inhibitors with 2,3-Fused Indole Scaffolds>, Formula: C19H34O2, the main research area is structure preparation kinesin spindle protein inhibitor fused indole scaffold.
Mitotic kinesin spindle protein (KSP) is involved in the assembly of the bipolar spindle during cell division. On the basis of a common 2,3-fused indole substructure within the complex frameworks of terpendole E and other KSP inhibitors, the carbazoles with a bulky alkyl group were identified as a novel KSP inhibitory scaffold. Addnl., among several naturally occurring cell growth inhibitors with 2,3-fused indole structures, β-carboline alkaloids, harman and harmine, showed moderate inhibition of KSP.
Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics