Meyhoff, Ulrich; Riber, Ulla; Boas, Ulrik published the artcile< Convergent synthesis of degradable dendrons based on L-malic acid>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is polyester dendrimer degradable dendron malic acid convergent preparation.
New degradable polyester dendrons based on the cellular tricarboxylic acid cycle component L-malic acid were synthesized up to the third generation by convergent synthesis. The dendron wedges could be introduced in a stepwise, highly regioselective fashion. HMBC-NMR revealed that the C1-carbonyl on malic acid was exclusively esterified, before the reaction of the second dendron wedge at C4 took place. Degradation studies on a first generation dendron analyzed by HPLC showed that hydrolytic degradation of the dendron most profoundly takes place at pH 4 and pH 9 with the highest degradation rate at alk. pH. NMR shows that the dendron degrades to malic acid and fumaric acid derivatives Preliminary studies performed in the cell culture show low toxicity of the dendrons in concentrations of up to 50 μg mL-1.
New Journal of Chemistry published new progress about Biodegradable medical goods. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics