《The in-vitro biocompatibility of ureido-pyrimidinone compounds and polymer degradation products》 was written by Besseling, Paul J.; Mes, Tristan; Bosman, Anton W.; Peeters, Joris W.; Janssen, Henk M.; Bakker, Maarten H.; Fledderus, Joost O.; Teraa, Martin; Verhaar, Marianne C.; Gremmels, Hendrik; Dankers, Patricia Y. W.. Reference of N-Boc-1,6-DiaminohexaneThis research focused onureido pyrimidinone compound polymer degradation product biocompatibility. The article conveys some information:
Supramol. biomaterials based on ureido-pyrimidinone (UPy) moieties are versatile polymer materials as their function can be tailored to the application. These UPy-materials can be designed into polymer coatings, self-healing polymers, hydrogels and elastomers. The biocompatibility of UPy-based materials and their degradation products is a long-term success requirement for many regenerative medicine and biomedical applications. Earlier research has shown that UPy-based materials and polymers display no immediate toxic effects, but in-depth in-vitro studies on potential UPy-polymer degradation products have not been executed. Owing to their resemblance to naturally occurring purines and pyrimidines, UPy-compounds and their degradation products could potentially initiate an immune response or be mutagenic. Accordingly, 11 selected UPy-compounds were synthesized, and their effect on cell viability, wound healing, and their immunogenicity and potential mutagenic potential, were studied. We showed that low mol. weight degradation products of UPy-based biomaterials do not affect cell viability, nor do these interfere with several aspects of endothelial function including proliferation, angiogenic sprouting and cellular migration even in levels exceeding plausibly attainable concentrations Furthermore, the compounds are neither immunogenic nor mutagenic, showing that UPy-biomaterials exhibit good biocompatibility in vitro, and could in principle be used in humans. In addition to this study using N-Boc-1,6-Diaminohexane, there are many other studies that have used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Reference of N-Boc-1,6-Diaminohexane) was used in this study.
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Reference of N-Boc-1,6-Diaminohexane
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