An, Xiaoying; Gao, Lei; Wang, Mingliang; Wu, Haitao; Wang, Lanzhi published an article in 2021. The article was titled 《One-pot synthesis of 1,5-benzodiazepine-2,3-dicarboxylates via three-component domino reactions in the presence of γ-Fe2O3@SiO2/Ce(OTf)3》, and you may find the article in Chemistry of Heterocyclic Compounds (New York, NY, United States).Product Details of 4949-44-4 The information in the text is summarized as follows:
Novel, efficient and environmentally friendly approaches was developed for the synthesis of 1,5-benzodiazepine-2,3-dicarboxylates I [R1 = H, Me, Cl, Br; R2 = Me, Et, Ph; R3 = Me, Et, Pr] and II by one-pot three-component domino reactions in the presence of a catalytic amount of γ-Fe2O3@SiO2/Ce(OTf)3 in EtOH at ambient temperature A total of synthesized 2,5-dihydro-1H-1,5-benzodiazepine-2,3-dicarboxylates I and 2-methyl-2,3-dihydro-1H-1,5-benzodiazepine-2,3-dicarboxylates II with enamine or imine structure of the heterocycle, resp., were obtained in good yields by reacting substituted 1,2-phenylenediamine, β-carbonyl esters and Et glyoxylate or Et pyruvate. One-pot reactions were successfully realized to form one new cycle and four new bonds (one C-C, two C-N, one C=C or two C-C, one C-N, one C=N). The salient features of this reaction included short reaction time, mild reaction conditions, moderate to excellent yields, recyclability of the catalyst, and wide substrate scope.Ethyl 3-oxopentanoate(cas: 4949-44-4Product Details of 4949-44-4) was used in this study.
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Product Details of 4949-44-4
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