Almeida, Santos Claudia Lais Araujo; Macedo, Santos Jonh Anderson; Alves, Caiana Rodrigo Ribeiro; Maria, Souza Silvia; Rufino, Freitas Jucleiton Jose; Gadelha, Militao Gardenia Carmem; Rufino, Freitas Juliano Carlo published an article in 2021. The article was titled 《Synthesis, antineoplastic activity and in silico studies of (S)-N-(1-hydroxy-3-methylbutan-2-yl)-3-(p-tolyl)-1,2,4-oxadiazole-5-carboxamide》, and you may find the article in Research Journal of Chemistry and Environment.Electric Literature of C4H5ClO3 The information in the text is summarized as follows:
In this work, authors reports the synthesis, antineoplastic evaluation and in silico study of a new 1,2,4-oxadiazole. The (S)-N-(1-hydroxy-3-methylbutan-2-yl)-3-(p-toluyl)-1,2,4-oxadiazole-5-carboxamide was obtained after two reaction steps in excellent yield. Although it has shown low activity in relation to the MCF-7, HCT116 and HL60 tumor cell lines, the mol. docking study indicates that this compound acts in the colchicine site and can inhibit tubulin polymerization From the calculation of pharmacokinetic properties by the SwissADME and Osiris Property Explorer programs, it is possible to infer that the compound meets the Lipinski rules presenting good oral bioavailability and low toxicity. The experimental part of the paper was very detailed, including the reaction process of Ethyl oxalyl monochloride(cas: 4755-77-5Electric Literature of C4H5ClO3)
Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Electric Literature of C4H5ClO3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics