Zou, Ying; Fahmi, Nour Eddine; Vialas, Corine; Miller, Guy M.; Hecht, Sidney M. published the artcile< Total Synthesis of Deamido Bleomycin A2, the Major Catabolite of the Antitumor Agent Bleomycin>, Formula: C12H24N2O4, the main research area is deamido bleomycin A2 total synthesis; demethyl deamido bleomycin A2 total synthesis; aglycon deamido bleomycin A2 total synthesis; DNA relaxation cleavage deamido bleomycin A2.
This work describes the synthesis of deamido-demethyl-bleomycin A2, I (R = SMe) and deamido-bleomycin A2, I (R = SMe2), as well as their resp. aglycons. Amino ester II was the key intermediate for I. Synthetic deamido-bleomycin A2 was shown to be identical to the product formed by treatment of bleomycin A2 (BLM-A2) with bleomycin hydrolase, as judged by reversed-phase HPLC anal. and 1H NMR spectroscopy. Deamido-bleomycin A2 was found to retain significant DNA cleavage activity in DNA plasmid relaxation assays and had the same sequence selectivity of DNA cleavage as bleomycin A2. The most significant alteration of function noted in this study was a reduction in the ability of deamido-bleomycin A2 to mediate double-strand DNA cleavage, relative to that produced by BLM-A2.
Journal of the American Chemical Society published new progress about DNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, Formula: C12H24N2O4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics