Xiang, Lingling; Wu, Haiting; Liang, Yunshi; Deng, Huiying; He, Yiting; Xu, Qin; Zhang, Jing published the artcile< Ag(I)-Catalyzed rapid access to 2-amino-4-methylenethiazolines with potential applications in bioconjugation chemistry>, SDS of cas: 19241-24-8, the main research area is methylenethiazoline amino preparation chemoselective; propargylamine isothiocyanate addition cyclization silver catalyst tandem reaction.
An Ag(I)-catalyzed tandem addition-cyclization of isothiocyanate RNCS (R = Ph, cyclohexyl, i-Pr, etc.) and propargylamine was successfully applied to the synthesis of 2-amino-4-methylenethiazolines I. This route features an unprecedented fast reaction rate with full conversion reached within 10 min at room temperature for aromatic isothiocyanates and excellent chemoselectivity for exocyclic products. The application of this strategy is further highlighted by the accelerated bioconjugation of propargylamine with fluorescein isothiocyanate (FITC) under Ag(I)-catalysis.
Organic & Biomolecular Chemistry published new progress about Addition reaction. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics