Shi, Yang; Pan, Bo-Wen; Li, Wen-Chao; Wang, Qing; Wu, Qiong; Pan, Meng; Fu, Hong-Zheng published the artcile< Synthesis and biological evaluation of Isosteviol derivatives as FXa inhibitors>, HPLC of Formula: 19241-24-8, the main research area is isosteviol derivative preparation FXa inhibitor anticoagulant; FXa inhibitors; Isosteviol; Structural modification.
Firstly, a series of Isosteviol derivatives were synthesized and evaluated for FXa inhibitory activity. Among these compounds, the inhibitory activity of three compounds on FXa was better than that of Isosteviol. Secondly, surface plasmon resonance (SPR) assays were performed for selected compounds The three compounds have similar kinetic signatures, and affinity values were at μM level. Thirdly, two compounds displayed moderate-to-high anticoagulation activity and showed similar sensitivity to PT and aPTT. These findings will provide new insight into the exploration of FXa inhibition.
Bioorganic & Medicinal Chemistry Letters published new progress about Anticoagulants. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, HPLC of Formula: 19241-24-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics