Rawal, Viresh H.; Cava, Michael P. published the artcile< Photocyclization of pyrrole analogs of stilbene: an expedient approach to antitumor agent CC-1065>, Recommanded Product: Ethyl 5-formyl-1H-pyrrole-2-carboxylate, the main research area is oxidation photochem cyclization pyrrolylethene; pyrroloindole; thienoindole; furoindole; benzindole.
Heterocycles were converted into pyrrole analogs of stilbene and subsequently cyclized to give the tricyclic ring structure necessary for CC-1065 and its analogs. Thus, Wittig reaction of the phosphonium salt I (R = Me) with the aldehydes II (X = NMe, S, O, R1 = H) and 4-MeOC6H4CHO gave 84-90% Wittig olefination products, which underwent oxidative photocyclization to give 38-80% tricyclic product III (X = NMe, S, O, R = Me, R1 = H) and IV. Analogously, Wittig reaction of I (R = CH2Ph) with II (X = NCH2Ph, R1 = CO2Et) gave, after oxidative cyclization, 78% III (X = NCH2Ph, R = CH2Ph, R1 = CO2Et), which on selective reduction of the more electron rich side gave the corresponding tricyclic phosphodiesterase type unit.
Journal of the Chemical Society, Chemical Communications published new progress about Oxidative cyclization. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Recommanded Product: Ethyl 5-formyl-1H-pyrrole-2-carboxylate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics