Montagna, Valentina; Haupt, Karsten; Gonzato, Carlo published the artcile< RAFT coupling chemistry: a general approach for post-functionalizing molecularly imprinted polymers synthesized by radical polymerization>, Recommanded Product: 2-Ethyl-2-((methacryloyloxy)methyl)propane-1,3-diyl bis(2-methylacrylate), the main research area is RAFT coupling chem imprinted polymer radical polymerization.
Molecularly imprinted polymers (MIPs) are well-known as antibody mimics, with binding properties for their target on a par with those of biomacromols. such as antibodies or enzymes. A great majority of MIPs is nowadays synthesized by free-radical polymerization (FRP), owing to the mild reaction conditions, tolerance for monomer and solvent impurities and high flexibility in terms of polymerization setups. Nevertheless, FRP MIPs lack suitable functionalities for a further elaboration of their structures via, for instance, extension with consecutive blocks. This results in practical limitations for FRP imprinted scaffolds in terms of adapting them to a given application. In this work, we show that FRP MIPs can easily be functionalized with “”living”” moieties for chain extension, by coupling a chain transfer (RAFT) agent to the ubiquitous unreacted double bonds on the MIP surface. Imprinted nanoparticles synthesized by precipitation polymerization, as well as microparticles obtained by bulk polymerization and mech. milling, were reacted with a dithioester or a trithiocarbonate in the presence of a radical source. This resulted in RAFT coupling which allowed the surface grafting of polymer brushes, while the imprinted scaffolds retained their binding properties in terms of template affinity and selectivity. Upon extension with poly(N-isopropylacrylamide) p(NIPAm), RAFT-coupled MIPs also acquired excellent binding properties in aqueous media, compared to unmodified particles which just exhibited non-specific binding. Thus, this easy approach, which takes advantage of a common feature of crosslinked particles obtained by FRP, is expected to be of general interest due to the easy post-modification and fine-tuning of the material’s surface properties.
Polymer Chemistry published new progress about Dithiocarboxylic acids, esters Role: PAC (Pharmacological Activity), BIOL (Biological Study). 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Recommanded Product: 2-Ethyl-2-((methacryloyloxy)methyl)propane-1,3-diyl bis(2-methylacrylate).
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