Lou, Jiang; He, Yuan; Li, Yunlong; Yu, Zhengkun published the artcile< Transition-Metal-Promoted Direct C-H Cyanoalkylation and Cyanoalkoxylation of Internal Alkenes via Radical C-C Bond Cleavage of Cycloketone Oxime Esters>, SDS of cas: 112-63-0, the main research area is cyanoalkylated alkene preparation cyanoalkoxylation bond cleavage cycloketone oxime ester; cyanoalkoxylation internal alkene bond cleavage cycloketone oxime ester.
Transition-metal-catalyzed alkyl-Heck-type cross-coupling of olefinic C-H bonds has been a challenge in the C-H activation area. Herein, we report FeCl3-promoted efficient direct C-H cyanoalkylation of internal alkenes, i.e., ketene dithioacetals, with cycloketone oxime esters via radical C-C bond cleavage under the redox-neutral conditions. With CuCl2 as the catalyst under a dioxygen atm. direct C-H cyanoalkoxylation of the same internal alkenes was achieved. The cyanoalkylated tetrasubstituted alkene products could be diversely transformed to cyanoalkyl-functionalized N- and S-heterocyclic compounds The mechanistic studies have revealed that these C-H cyanoalkylation and cyanoalkoxylation reactions proceed through a radical pathway.
Advanced Synthesis & Catalysis published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (internal). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics