Liu, Zhi; Qiao, Jing; Nagy, Tamas; Xiong, May P. published the artcile< ROS-triggered degradable iron-chelating nanogels: Safely improving iron elimination in vivo>, Reference of 71195-85-2, the main research area is ROS responsive polymeric deferoxamine nanogel iron chelation therapy; Chelation therapy; Deferoxamine (DFO); Iron overload (IO); Nanogel; Reactive oxygen species (ROS).
Iron-mediated generation of highly toxic Reactive Oxygen Species (ROS) plays a major role in the process leading to iron overload-related diseases. The long-term s.c. administration of Deferoxamine (DFO) is currently clin.-approved to improve patient symptoms and survival. However, non-specific toxicity and short circulation times of the drug in humans often leads to poor patient compliance. Herein, thioketal-based ROS-responsive polymeric nanogels containing DFO moieties (rNG-DFO) were designed to chelate iron and to degrade under oxidative stimuli into fragments <10 nm to enhance excretion of iron-bound chelates. Serum ferritin levels and iron concentrations in major organs of IO mice decreased following treatment with rNG-DFO, and fecal elimination of iron-bound chelates increased compared to free DFO. Furthermore, rNG-DFO decreased iron mediated oxidative stress levels in vitro and reduced iron-mediated inflammation in the liver of IO mice. The study confirms that ROS-responsive nanogels may serve as a promising alternative to DFO for safer and more efficient iron chelation therapy. Journal of Controlled Release published new progress about Chelation. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Reference of 71195-85-2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics