Jovanovic, Predrag; Petkovic, Milos; Simic, Milena; Jovanovic, Milos; Tasic, Gordana; Crnogorac, Marija Djordjic; Zizak, Zeljko; Savic, Vladimir published the artcile< Stereocontrolled Synthesis of Highly Substituted trans α,β-Unsaturated Ketones with Potent Anticancer Properties from Glycals>, Quality Control of 4098-06-0, the main research area is stereocontrolled synthesis unsaturated ketone Heck ring opening glycal; anticancer unsaturated ketone.
A novel synthetic route for highly substituted conjugated ketones has been developed utilizing glycals as starting materials. The two-step process combined the Heck reaction/Lewis acid promoted ring opening to afford the products in 33-80 % overall yields and with a high level of trans stereoselectivity [e.g., I + 4-iodoanisole → II → III]. Since the products are essentially the aldols, this methodol. may be employed in some cases as an alternative synthetic route to the typical aldol condensation. Densely substituted, selectively protected conjugated ketones are synthetically attractive structures which, in our case, proved to be biol. equally appealing. Namely, they showed activity against several cancer cell lines, such as HeLa, K562, MDA-MB-453, in some instances overperforming cisplatin used as a standard
European Journal of Organic Chemistry published new progress about Antitumor agents. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Quality Control of 4098-06-0.
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