Hughes, Chambers C.; Kauffman, Christopher A.; Jensen, Paul R.; Fenical, William published the artcile< Structures, Reactivities, and Antibiotic Properties of the Marinopyrroles A-F>, Related Products of 252932-48-2, the main research area is antimicrobial antitumor marinopyrrole isolation preparation structure activity.
Cultivation of actinomycete strain CNQ-418, retrieved from a deep ocean sediment sample off the coast of La Jolla, CA, has provided marinopyrroles A-F. Sharing just 98% 16S rRNA gene sequence identity with S. sannurensis, the strain likely represents a new Streptomyces species. The metabolites contain an unusual 1,3′-bipyrrole core decorated with several chlorine and bromine substituents and possess marked antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). The congested N,C-biaryl bond establishes an axis of chirality that, for marinopyrroles A-E, is configurationally stable at room temperature Moreover, the natural products are fashioned strictly in the M-configuration. The Paal-Knorr condensation was adapted for the synthesis of the 1,3′-bipyrrole core. Halogenation of this material with N-bromosuccinimide cleanly furnished the 4,4′,5,5′-tetrahalogenated core that characterizes this class of marine-derived metabolites.
Journal of Organic Chemistry published new progress about Actinobacteria. 252932-48-2 belongs to class esters-buliding-blocks, and the molecular formula is C7H10N2O2, Related Products of 252932-48-2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics