Name: Diethyl cyclobutane-1,1-dicarboxylateIn 2011, Xu, Zhaohui;Jiang, Xintao;Liu, Hong;Liao, Weilin published 《Synthesis of polypropylene catalyst internal donor 1,1-cyclopentyl dimethanoldimethyl ether》. 《Shiyou Lianzhi Yu Huagong》published the findings. The article contains the following contents:
1,1-Cyclopentyl dimethanoldimethyl ether was synthesized from di-Et malonate and 1,4-dibromo butane by alkylation, ester reduction and etherification. The key factors affecting reactions were studied and the optimal reaction conditions were found as follows: (1) for alkylation, by using CsOH as catalyst and when di-Et malonate/CsOH/1,4-dibromobutane molar ratio was 1.0:2.2:1.4, the yield of cyclobutane-1,1-dicarboxylic acid di-Et ester was 93.0%; (2)for ester reduction, using anhydro-ZnCl2 as catalyst and when cyclopentyl-1,1-dicarboxylic acid di-Et ester/KBH4 molar ratio was 2.0:1.0, the yield of 1,1-cyclopentyl dimethanol was 88.1%; and (3)for etherification, using tetra-Bu ammonium bromide as catalyst and when 1,1-cyclopentyl dimethanol/NaOH/dimethyl carbonate mass ratio was 1.0:8.0:2.4, the yield of 1,1-cyclopentyl dimethanoldimethyl ether was 61.2%.Diethyl cyclobutane-1,1-dicarboxylate (cas: 3779-29-1) were involved in the experimental procedure.
Diethyl 1,1-cyclobutanedicarboxylate(cas:3779-29-1 Name: Diethyl cyclobutane-1,1-dicarboxylate) also has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit the cb2 receptor and thus interfere with prostaglandin synthesis.
Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics