Bokharaei-Salim, Farah; Esghaei, Maryam; Khanaliha, Khadijeh; Kalantari, Saeed; Marjani, Arezoo; Fakhim, Atousa; Keyvani, Hossein published the artcile< HIV-1 reverse transcriptase and protease mutations for drug-resistance detection among treatment-experienced and naive HIV-infected individuals>, Formula: C19H34O2, the main research area is HIV infection drug resistance reverse transcriptase protease mutation.
The current study aimed at assessing the prevalence of HIV-1 DRMs among naive and treatment-experienced HIV-1-infected patients in Iran. Methods: From Apr. 2013 to Sept. 2018, the HIV-1 protease and reverse transcriptase genes were amplified and sequenced in plasma specimens of 60 newly diagnosed antiretroviral-naive individuals and 46 participants receiving antiretroviral therapies (ARTs) for at least six months with an HIV viral load of more than 1000 IU/mL to determine the HIV-1 DRMs and subtypes. Results: The SDRMs, D67N and D67E, belonged to the NRTIs class in two patients and K103N and V106A belonged to the NNRTIs class in three patients. Among the 46 ART-experienced participants, 33 (71.7%) carried HIV-1 variants with SDRMs (9.1% against PIs, 78.8% against NRTIs, and 100% against NNRTIs). M46I and I47V were the most common mutations for PIs, M184V was the most common mutation for the NRTIs, and K103N/S was the most common mutation for NNRTIs. Phylogenetic anal. of the polymerase region showed that all of the 46 HIV-1-infected patients who failed on ART carried CRF35_AD. The moderate prevalence of SDRMs (8.3%) in treatment-naive and ART-failed (77.1%) Iranian patients with HIV-1-infection emphasizes the need for systematic viral load monitoring, expanding drug resistance testing, carefully surveilling individuals on ART regimens, and facilitating access to new antiretrovirals by health authorities.
PLoS One published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.
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