Month: October 2022

Miklas, Jason W.; Levy, Shiri; Hofsteen, Peter; Mex, Diego Ic; Clark, Elisa; Muster, Jeanot; Robitaille, Aaron M.; Sivaram, Gargi; Abell, Lauren; Goodson, Jamie M.; Pranoto, Inez; Madan, Anup; Chin, Michael T.; Tian, Rong; Murry, Charles E.; Moon, Randall T.; Wang, Yuliang; Ruohola-Baker, Hannele published the artcile< Amino acid primed mTOR activity is essential for heart regeneration>, Application of C19H34O2, the main research area is heart disease regeneration mTOR amino acid; Biological sciences; Cell biology; Tissue Engineering.

Heart disease is the leading cause of death with no method to repair damaged myocardium due to the limited proliferative capacity of adult cardiomyocytes. Curiously, mouse neonates and zebrafish can regenerate their hearts via cardiomyocyte de-differentiation and proliferation. However, a mol. mechanism of why these cardiomyocytes can re-enter cell cycle is poorly understood. Here, we identify a unique metabolic state that primes adult zebrafish and neonatal mouse ventricular cardiomyocytes to proliferate. Zebrafish and neonatal mouse hearts display elevated glutamine levels, predisposing them to amino-acid-driven activation of TOR, and that TOR activation is required for zebrafish cardiomyocyte regeneration in vivo. Through a multi-omics approach with cellular validation we identify metabolic and mitochondrial changes during the first week of regeneration. These data suggest that regeneration of zebrafish myocardium is driven by metabolic remodeling and reveals a unique metabolic regulator, TOR-primed state, in which zebrafish and mammalian cardiomyocytes are regeneration competent.

iScience published new progress about Amino acid transporter ASCT2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gu, Jing; Zhang, Jun; Wang, Yazhuo; Li, Denian; Huang, Hongyu; Yuan, Haoran; Chen, Yong published the artcile< Efficient transfer hydrogenation of biomass derived furfural and levulinic acid via magnetic zirconium nanoparticles: Experimental and kinetic study>, SDS of cas: 112-63-0, the main research area is furfural levulinic acid hydrogenation magnetic zirconium nanoparticle catalyst preparation.

A series of magnetic zirconium nanoparticles with varied Zr/Fe molar ratios were synthesized and developed as acid-base bifunctional catalysts in the catalytic transfer hydrogenation (CTH) of biomass-derived furfural (FFR) and levulinic acid (LA) using 2-propanol as both hydrogen donor and solvent. Zirconium constituents coated on nano-sized Fe3O4 endowed the catalysts with abundant acid-base sites, moderate surface areas (94.0-187.6 m2/g) and pore sizes (3.42-9.51 nm), thus giving nearly 100% yields of furfuryl alc. (FA) and γ-valerolactone (GVL) after 2 h of reaction. Particularly, competitive activation energy (Ea) for the CTH of FFR into FA over Zr1Fe1-300 was as low as 50.9 kJ/mol. Moreover, the easily separable nanocatalyst Zr1Fe1-150 was also applicable to CTH of various alkyl levulinates into GVL in high efficiency and could be reused for multiple cycles without obvious loss of its catalytic performance in the transfer hydrogenation of LA.

Industrial Crops and Products published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Majchrzak-Celinska, Aleksandra; Kleszcz, Robert; Studzinska-Sroka, Elzbieta; Lukaszyk, Agnieszka; Szoszkiewicz, Anna; Stelcer, Ewelina; Jopek, Karol; Rucinski, Marcin; Cielecka-Piontek, Judyta; Krajka-Kuzniak, Violetta published the artcile< Lichen Secondary Metabolites Inhibit the Wnt/β-Catenin Pathway in Glioblastoma Cells and Improve the Anticancer Effects of Temozolomide>, Application of C19H34O2, the main research area is Wnt/β-catenin pathway; blood-brain barrier permeability; caperatic acid; glioblastoma; lichen secondary metabolites; microarrays; physodic acid; temozolomide.

Lichens are a source of secondary metabolites with significant pharmacol. potential. Data regarding their possible application in glioblastoma (GBM) treatment are, however, scarce. The study aimed at analyzing the mechanism of action of six lichen secondary metabolites: atranorin, caperatic acid, physodic acid, squamatic acid, salazinic acid, and lecanoric acid using two- and three-dimensional GBM cell line models. The parallel artificial membrane permeation assay was used to predict the blood-brain barrier penetration ability of the tested compounds Their cytotoxicity was analyzed using the MTT test on A-172, T98G, and U-138 MG cells. Flow cytometry was applied to the anal. of oxidative stress, cell cycle distribution, and apoptosis, whereas qPCR and microarrays detected the induced transcriptomic changes. Our data confirm the ability of lichen secondary metabolites to cross the blood-brain barrier and exert cytotoxicity against GBM cells. Moreover, the compounds generated oxidative stress, interfered with the cell cycle, and induced apoptosis in T98G cells. They also inhibited the Wnt/β-catenin pathway, and this effect was even stronger in case of a co-treatment with temozolomide. Transcriptomic changes in cancer related genes induced by caperatic acid and temozolomide were the most pronounced. Lichen secondary metabolites, caperatic acid in particular, should be further analyzed as potential anti-GBM agents.

Cells published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xing, Xiu; Liu, Yan; Shi, Ming-Liang; Li, Kun; Fan, Xin-Yue; Wu, Zhong-Liu; Wang, Na; Yu, Xiao-Qi published the artcile< Preparation of chiral aryl alcohols: a controllable enzymatic strategy via light-driven NAD(P)H regeneration>, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate, the main research area is rhodamine B labeled UiO 67 immobilized enzyme catalyst preparation; alc preparation enantioselective; ketone reduction photochem enzyme catalyst.

Controllable and mild photoenzymic production of chiral alcs. RCH(OH)R1 [R = Ph, 4-pyridyl, 2-naphthyl, etc.; R1 = H, Me, CH2CO2Me, etc.] was realized by coupling a versatile photochem. NAD(P)H regeneration system with (R)- or (S)-selective ketoreductases. The efficiency of NAD(P)H regeneration was improved using a rhodium functionalized metal organic framework, namely Rh-UiO-67, to adjust and control electron transport and electron utilization. Furthermore, six different ketoreductases could be successfully immobilized on Rh-UiO-67 and combined with the light-driven NAD(P)H regeneration system to produce chiral aryl alcs. Various chiral alcs. with complementary (R)- and (S)-conformations could be constructed by this method with high yields (97%) and excellent stereoselectivity (>99% ee).

New Journal of Chemistry published new progress about Alcohols, chiral Role: SPN (Synthetic Preparation), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Li Qun; Yap, Beatrice Swee Min; Wang, Rong; Neoh, Koon-Gee; Kang, En-Tang; Fu, Guo Dong published the artcile< Catecholamine-Induced Electroless Metallization of Silver on Silica@Polymer Hybrid Nanospheres and Their Catalytic Applications>, HPLC of Formula: 71195-85-2, the main research area is silver electroless metalization catechol modified polyacrylate silica catalyst.

Narrowly dispersed raspberry-like SiO2@poly(dopamine acrylamide-co-methacrylic acid-co-ethylene glycol dimethacrylate)/Ag (or SiO2@PDA/Ag) composite nanospheres were synthesized via a combination of sol-gel reaction, distillation-precipitation polymerization, reactive ester-amine reaction, and electroless metalization. In this approach, SiO2@poly(pentafluorophenyl acrylate-co-methacrylic acid-co-ethylene glycol dimethacrylate) (or SiO2@PPFA) core-shell nanospheres were first prepared by distillation-precipitation polymerization, using the SiO2-3-(trimethoxysilyl)propyl methacrylate (SiO2-MPS) nanospheres from sol-gel reaction as seeds. The reactive pentafluorophenyl (PFP) ester moieties on SiO2@PPFA nanospheres can readily react with dopamine hydrochloride to form amide linkages with no side reaction under a mild condition. The catecholamine moieties in the resulting SiO2@PDA nanospheres were utilized for simultaneous reduction of Ag+ ions and coordinative binding of the metal nanoparticles. The SiO2-MPS, SiO2@PPFA, and SiO2@PDA nanospheres as well as the raspberry-like SiO2@PDA/Ag composite nanospheres were characterized by field-emission transmission electron microscopy (FETEM), thermogravimetric anal. (TGA), dynamic light scattering (DLS), XPS, and FT-IR spectroscopy. Furthermore, the as-synthesized SiO2@PDA/Ag composite nanospheres were explored for the catalytic reduction of p-nitrophenol and degradation of rhodamine 6G (R6G) dye.

Industrial & Engineering Chemistry Research published new progress about Decomposition catalysts. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, HPLC of Formula: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fan, Yi Chiao; Kwon, Ohyun published the artcile< Phosphine/Palladium-Catalyzed Syntheses of Alkylidene Phthalans, 3-Deoxyisoochracinic Acid, Isoochracinic Acid, and Isoochracinol>, Electric Literature of 112-63-0, the main research area is alkylidene phthalan preparation phosphine catalyst Michael palladium catalyst Heck; stereoselective synthesis alkylidene phthalan Michael Heck catalytic.

In this study, we used sequential catalysis-PPh3-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization-to construct complex functionalized alkylidene phthalans, e.g., I (R1 = H, R, R2 = H, OCH2Ph, OMe, CF3, etc., R3 = H, OCH2Ph, OMe, Me, R4 = H, Me, MeO), rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael-Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid II (X = none, Y = CO2H) isoochracinic acid II (X = O, Y = CO2H), and isoochracinol II (X = O, Y = CH2OH).

Organic Letters published new progress about Diastereoselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Barbato, Cinzia; Baldino, Salvatore; Ballico, Maurizio; Figliolia, Rosario; Magnolia, Santo; Siega, Katia; Herdtweck, Eberhardt; Strazzolini, Paolo; Chelucci, Giorgio; Baratta, Walter published the artcile< OsXCl(phosphine)2(diamine) and OsXCl(diphosphine)(diamine) (X = Cl, H) Complexes for Ketone Hydrogenation>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is diphoshine derivative coordinative substitution osmium chloride complex; crystal structure ferrocenediphosphino osmium diamine chloride complex; mol structure ferrocenediphosphino osmium diamine chloride complex; ferrocenediphosphino osmium diamine chloride complex preparation catalyst hydrogenation.

The Os complex trans-[OsCl2(PPh3)2(en)] (2) was prepared by reaction of [OsCl2(PPh3)3] (1a) with ethylenediamine (en), whereas the diphosphine derivatives trans-[OsCl2(dppf)(NN)] (NN = en, 3; bn = 1,4-butanediamine, 4) and trans-[OsCl2(dpbp)(en)] (5) were obtained from 1a, dppf or dpbp and the corresponding NN ligand in CH2Cl2 or toluene. An x-ray diffraction study was provided for 3. The isolation of the chiral derivatives trans-[OsCl2(diphosphine)((R,R)-dpen)] (diphosphine = dppf, 6; dpbp, 7; (R,R)-skewphos, 8) was achieved by reacting 1a with the diphosphine and (R,R)-dpen in toluene. Treatment of the precursor [Os2Cl4(P(m-tolyl)3)5] (1b) with en afforded [OsCl2(P(m-tolyl)3)2(en)] (9), while reaction of 1b with dppb and N,N-dmen gave [OsCl2(dppb)(N,N-dmen)] (10). The chiral derivatives [OsCl2(diphosphine)(NN)] (11-21) (diphosphine = (S)-MeObiphep, (R)-MeObiphep, (R)-xylMeObiphep, (R)-binap, (S)-xylbinap, (R)-xylbinap, (R,S)-Josiphos*; NN = en, (R,R)-dpen, (R)-daipen, (R,R)-dppn) were prepared from 1b and the corresponding diphosphine and NN ligands in toluene. The monohydride trans-[OsHCl(P(m-tolyl)3)2(en)] (22) was synthesized by reaction of 1b with H2 (1 atm) in the presence of NEt3, followed by addition of en in toluene. Similarly, trans-[OsHCl(dppf)(en)] (23) was synthesized from 1a, H2 and NEt3, followed by treatment with dppf and en. Complexes 2-5, 9, 10, 22 and 23 efficiently catalyzed the hydrogenation of acetophenone with H2 under low pressure (5 atm) at 60-70° in EtOH (1-2 mol% of NaOEt). The chiral derivatives 6-8 and 11-21 afforded the asym. hydrogenation of acetophenone with up to 90% ee (S/C = 10000) by combining bulky xylyl substituted MeObiphep or binap-type ligands with (R)-daipen or (R,R)-dpen ligands. Catalytic transfer hydrogenation of acetophenone was observed with 3, 6 and 7 (S/C = 2000) in iso-PrOH and in the presence of NaOiPr (2 mol%) at 60-82°.

Organometallics published new progress about Bidentate ligands Role: RCT (Reactant), RACT (Reactant or Reagent) (diamine and diphoshine derivatives). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sheng, Changting; Guo, Yang; Ma, Jing; Hong, Eun-Kyung; Zhang, Benyin; Yang, Yongjing; Zhang, Xiaofeng; Zhang, Dejun published the artcile< Metabolomic Profiling Reveals Protective Effects and Mechanisms of Sea Buckthorn Sterol against Carbon Tetrachloride-Induced Acute Liver Injury in Rats>, Formula: C19H34O2, the main research area is metabolomics sea buckthorn sterol hepatoprotective agent acute liver injury; acute liver injury; carbon tetrachloride; metabolomics; sea buckthorn sterol.

The present study was designed to examine the efficacy and protection mechanisms of sea buckthorn sterol (SBS) against acute liver injury induced by carbon tetrachloride (CCl4) in rats. Five-week-old male Sprague-Dawley (SD) rats were divided into six groups and fed with saline (Group BG), 50% CCl4 (Group MG), or bifendate 200 mg/kg (Group DDB), or treated with low-dose (Group LD), medium-dose (Group MD), or high-dose (Group HD) SBS. This study, for the first time, observed the protection of SBS against CCl4-induced liver injury in rats and its underlying mechanisms. Investigation of enzyme activities showed that SBS-fed rats exhibited a significant alleviation of inflammatory lesions, as evidenced by the decrease in cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and gamma-glutamyl transpeptidase (γ-GT). In addition, compared to the MG group, the increased indexes (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), total antioxidant capacity (T-AOC), and total protein (TP)) of lipid peroxidation and decreased malondialdehyde (MDA) in liver tissues of SBS-treated groups showed the anti-lipid peroxidation effects of SBS. Using the wide range of targeted technologies and a combination of means (UPLC-MS/MS detection platform, self-built database, and multivariate statistical anal.), the addition of SBS was found to restore the expression of metabolic pathways (e.g., L-malic acid, N-acetyl-aspartic acid, N-acetyl-l-alanine, etc.) in rats, which means that the metabolic damage induced by CCl4 was alleviated. Furthermore, transcriptomics was employed to analyze and compare gene expression levels of different groups. It showed that the expressions of genes (Cyp1a1, Noct, and TUBB6) related to liver injury were regulated by SBS. In conclusion, SBS exhibited protective effects against CCl4-induced liver injury in rats. The liver protection mechanism of SBS is probably related to the regulation of metabolic disorders, anti-lipid peroxidation, and inhibition of the inflammatory response.

Molecules published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (Noct). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meyer, Stephanie; Haefliger, Joel; Schaefer, Michael; Molloy, John J.; Daniliuc, Constantin G.; Gilmour, Ryan published the artcile< A Chiral Pentafluorinated Isopropyl Group via Iodine(I)/(III) Catalysis>, Product Details of C6H12O3, the main research area is fluoride enantioselective synthesis difluorination trifluoromethyl styrene catalyst; regioselective synthesis difluoronation; agrochemistry; bioisostere; conformation; fluorine; organocatalysis.

An I(I)/(III) catalysis strategy to construct an enantioenriched fluorinated isostere of the iPr group is reported. The difluorination of readily accessible α-CF3-styrenes is enabled by the in situ generation of a chiral ArIF2 species to forge a stereocentre with the substituents F, CH2F and CF3 (up to 95%, >20:1 vicinal:geminal difluorination). The replacement of the metabolically labile benzylic proton results in a highly preorganised scaffold as was determined by X-ray crystallog. (π→σ* and stereoelectronic gauche σ→σ* interactions). A process of catalyst editing is disclosed in which preliminary validation of enantioselectivity is placed on a structural foundation.

Angewandte Chemie, International Edition published new progress about Asymmetric catalysis. 24347-63-5 belongs to class esters-buliding-blocks, and the molecular formula is C6H12O3, Product Details of C6H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Xiangyang; Ho, Chi-Tang; Wan, Xiaochun; Zhu, Hui; Liu, Qiong; Wen, Zhen published the artcile< Changes of volatile compounds and odor profiles in Wuyi rock tea during processing>, Category: esters-buliding-blocks, the main research area is Wuyi rock tea Odor profile favor Odor activity value; Sensory evaluation Tea processing; Odor activity value (OAV); Odor profile; Rock flavor; Sensory evaluation; Tea processing; Wuyi rock tea.

Wuyi rock tea (WRT), is one kind of oolong tea and widely appreciated for its typical ′rock flavor′. The odor characteristics of WRT during processing were comprehensive investigated by gas chromatog.-mass spectrometry, sensory evaluation and odor activity value (OAV). Alcs., alkenes and esters were the main volatiles formed during tea processes, but the WRT contained more heterocyclic compounds, among which 15 N-containing volatiles were newly identified in this study, accounting for 60.52% of total amounts of volatiles in WRT. In response, the original green and chem. odors converted to roasted and woody odors, and full fire processing was effective to enhance roasted, floral and woody odors, weaken chem. odor. 2-Ethyl-3,5-dimethylpyrazine (OAV 4.71) was confirmed as the aroma-active compound of WRT with roasted odor by aroma recombination experiment In addition, strong roasted, floral and moderate woody odors were perceived as the outline of ′rock flavor′ in WRT aroma. These results provide theor. basis for processing and quality control of WRT.

Food Chemistry published new progress about Lactones Role: ANT (Analyte), PRP (Properties), ANST (Analytical Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics