Month: September 2022

Tong, Huiquan;Cao, Changwei;Du, Yanli;Liu, Yong;Huang, Wei published 《Ultrasonic-assisted phosphate curing: a novel approach to improve curing rate and chicken meat quality》 in 2022. The article was appeared in 《International Journal of Food Science and Technology》. They have made some progress in their research.Related Products of 112-62-9 The article mentions the following:

The effects of ultrasound-assisted phosphate curing (UPC), phosphate curing (PC), and deionised water curing (DC) on the quality of chicken breast meat were investigated. The anal. of tissue sections, low-field NMR (LF-NMR), and headspace solid-phase microextraction gas-phase mass spectrometry (HS-SPME-GC-MS) of water distribution, myofibrillary structure, and volatile components of the meat samples were performed to reveal the mechanism. Also, the curing rate, water holding capacity (WHC), and shear force of meat were assessed. The results revealed that ultrasonic-assisted salting improved the meat salting rate, WHC, and tenderness by mech. destroying the muscle fiber structure, increasing the space between the muscle fiber bundles, promoting water migration and uniform distribution, and reducing water freedom in the treated samples. In addition, HS-SPME-GC-MS anal. revealed that PC significantly reduced the content of volatile flavor components in the chicken breast meat compared with DC (P < 0.05); however, the combination treatment with PC and ultrasonic curing could reconstruct the flavor loss caused by phosphate. Thus, our cumulative results suggest that the ultrasonic technol. may effectively assist the processing technol. in improving the quality of meat and reconstructing the flavor loss in meat products. To complete the study, the researchers used Methyl oleate (cas: 112-62-9) .

Methyl oleate(cas: 112-62-9) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of oleic acid with methanol.Related Products of 112-62-9 Methyl oleate(cas: 112-62-9) is an intermediate for detergents, emulsifiers, wetting agents, stabilizers, textile treatments, plasticizers for duplicating inks, rubbers, waxes etc.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of C16H32O2《Selection of drying techniques for Pingyin rose on the basis of physicochemical properties and volatile compounds retention》 was published in 2022. The authors were Xu, Baoguo;Feng, Min;Chitrakar, Bimal;Wei, Benxi;Wang, Bo;Zhou, Cunshan;Ma, Haile;Wang, Bin;Chang, Lu;Ren, Guangyue;Duan, Xu, and the article was included in《Food Chemistry》. The author mentioned the following in the article:

Awareness of edible rose being beneficial for health has attracted researchers in exploring different rose products. The study aimed to investigate effects of vacuum freeze drying (VFD), hot air drying (HAD), heat pump drying (HPD), relative humidity drying (RHD) and catalytic IR drying (CID) on the physicochem. properties, and volatile organic compounds (VOCs) of Pingyin roses. Results showed that the VFD roses had significantly (p < 0.05) bright color, complete tissue cells, low shrinkage, and good plasma membrane permeability. CID roses showed the highest total phenols content (164.09 ± 0.88 mg/g) and the strongest antioxidant activity. Besides, the odor is the most crucial indicator for dried roses. VFD can well prevent the odor from diminishing/destroying and preserve the natural smell of rose. Thermal drying including HAD, HPD, RHD, and CID, could cause significant losses of VOCs. Consequently, the findings can provide the scientific basis for future large-scale production of dried rose products. And Ethyl tetradecanoate (cas: 124-06-1) was used in the research process.

Ethyl tetradecanoate(cas: 124-06-1) is a natural product found in Psidium guajava, Litchi chinensis, and other organisms.Synthetic Route of C16H32O2Ethyl myristate is a long-chain fatty acid ethyl ester resulting from the formal condensation of the carboxy group of myristic acid with the hydroxy group of ethanol.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Isabelle;Na, Mihwa;O’Brien, Devin;Parakhia, Rahul;Alepee, Nathalie;Westerink, Walter;Eurlings, Irene;Api, Anne Marie published 《Assessment of the skin sensitization potential of fragrance ingredients using the U-SENS assay》 in 2022. The article was appeared in 《Toxicology In Vitro》. They have made some progress in their research.COA of Formula: C15H28O2 The article mentions the following:

The U-SENS assay was developed to address the third key event of the skin sensitization adverse outcome pathway (AOP) and is described in OECD test guideline 442E, Annex II. A dataset of 68 fragrance ingredients comprised of 7 non-sensitizers and 61 sensitizers was tested in the U-SENS assay. The potential for fragrance ingredients to activate dendritic cells, measured by U-SENS, was compared to the sensitization potential determined by weight of evidence (WoE) from historical data. Of the non-sensitizers, 4 induced CD86 cell surface marker ≥1.5-fold while 3 did not. Of the sensitizers, 50 were predicted to be pos. in U-SENS, while the remaining 11 were neg. Pos. and neg. predictive values (PPV and NPV) of U-SENS were 93% and 21%, resp. No specific chem. property evaluated could account for misclassified ingredients. Assessment of parent and metabolite protein binding alerts in silico suggests that parent chem. metabolism may play a role in CD86 activation in U-SENS. Combining the U-SENS assay in a “2 out of 3” defined approach with the direct peptide reactivity assay (DPRA) and KeratinoSens predicted sensitization hazard with PPV and NPV of 97% and 24%, resp. Combining complementary in silico and in vitro methods to the U-SENS assay should be integrated to define the hazard classification of fragrance ingredients, since a single NAM cannot replace animal-based methods. The experimental procedure involved many compounds, such as Oxacyclohexadecan-2-one (cas: 106-02-5) .

Oxacyclohexadecan-2-one(cas:106-02-5) is a monomer used to make PGA-co-pentadecalactone polymers to be used in the development of directly compressed prolonged release tablets of slightly soluble drugs such as ketoprofen.COA of Formula: C15H28O2It may be used for the synthesis of poly(pentadecanolide) (PPDL) by Novozyme 435 catalyzed ring-opening polymerization.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of C6H18K2O24P6《Synthesis, solid-state characterization and solution studies of new phytate compounds with Cu(II) and 1,10-phenanthroline: progress in the structural elucidation of phytate coordinating ability》 was published in 2016. The authors were Quinone, D.;Veiga, N.;Torres, J.;Castiglioni, J.;Bazzicalupi, C.;Bianchi, A.;Kremer, C., and the article was included in《Dalton Transactions》. The author mentioned the following in the article:

Within all the eukaryotic cells there is an important group of biomols. that was potentially related to signalling functions: myo-inositol phosphates (InsP_s). In nature, the most abundant member of this family is the so called phytate (InsP₆, L^12-). The importance of the interaction of InsP₆ with cations was recognized during the last few years, and any attempt to know the function of this mol. in eukaryotic cells must include the fact that InsP₆ will be strongly associated with simple inorganic or organic ammonium cations. The authors expand on the authors’ earlier findings by studying the systems phen-phytate (phen = 1,10-phenanthroline) and Cu(II)-phen-phytate. The structures of (Hphen)₄(H₈L)·7.5H₂O and [Cu₅(H₇L)₂(H₂O)₂(phen)₅]·23H₂O are presented. Solution studies of the binary and ternary systems were also performed by potentiometric titrations at 37.0° and 0.15M ionic strength. The work was completed with a mol. modeling study. All this information is essential in the process of gaining reliable structural knowledge about the most important InsP₆ species in the in vitro and in vivo experiments, and how these features modulate their probable biol. functions. CCDC 1473692 and 1473693 for 1 and 2.rel-(1R,2r,3S,4R,5s,6S)-Cyclohexane-1,2,3,4,5,6-hexayl hexakis(dihydrogen phosphate), dipotassium salt (cas: 129832-03-7) were involved in the experimental procedure.

rel-(1R,2r,3S,4R,5s,6S)-Cyclohexane-1,2,3,4,5,6-hexayl hexakis(dihydrogen phosphate), dipotassium salt (cas:129832-03-7) is also known as Inositol hexakisphosphate. Phytic acid dipotassium salt is a potent chelator of divalent and trivalent cations, and a major determinant of zinc bioavailability.Electric Literature of C6H18K2O24P6

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Today I want to share an article with you. The article is 《Synthesis of barbacic acid》,you can find this article in 《Journal of Asian Natural Products Research》. The following contents are mentioned:

A new approach for the synthesis of the active barbatic acid has been achieved in eight steps with 22.3% total yield by using com. available Me atratate as starting material. This synthesis provides access to multi-gram quantities of barbatic acid with good purity for reference supplies and further anal. and toxicol. investigations. To complete the study, the researchers used Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Safety of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Long, Jiao;Gao, Wenchao;Guan, Yuqing;Lv, Hui;Zhang, Xumu published 《Nickel-Catalyzed Highly Enantioselective Hydrogenation of β-Acetylamino Vinylsulfones: Access to Chiral β-Amido Sulfones》 in 2018. The article was appeared in 《Organic Letters》. They have made some progress in their research.Electric Literature of C9H10O2 The article mentions the following:

In the presence of Ni(OAc)₂ and (S)-Binapine in 1:9 MeOH/F₃CCH₂OH (TFE), β-(acetylamino)-α,β-unsaturated sulfones (Z)-RC(NHCOMe):CHSO₂R¹ (R = Ph, 4-MeC₆H₄, 3-MeC₆H₄, 4-t-BuC₆H₄, 4-MeOC₆H₄, 4-ClC₆H₄, 3-ClC₆H₄, 4-BrC₆H₄, 4-FC₆H₄, 3-FC₆H₄, 4-F₃CC₆H₄, 2-thienyl, cyclohexyl, Et; R¹ = Me, Ph) underwent enantioselective hydrogenation to give β-(acetylamino) sulfones (S)-RCH(NHCOMe)CH₂SO₂R¹ (R = Ph, 4-MeC₆H₄, 3-MeC₆H₄, 4-t-BuC₆H₄, 4-MeOC₆H₄, 4-ClC₆H₄, 3-ClC₆H₄, 4-BrC₆H₄, 4-FC₆H₄, 3-FC₆H₄, 4-F₃CC₆H₄, 2-thienyl, cyclohexyl, Et; R¹ = Me, Ph) in 75-95% yields and in 90->99% ee. The 1:1 (E):(Z) mixture of PhC(NHCOMe):CHSO₂Ph underwent enantioselective hydrogenation to give (S)-PhCH(NHCOMe)CH₂SO₂Ph in 85% yield and 97% ee; in a sep. hydrogenation reaction performed on gram scale, 0.2 mol% of the nickel catalyst was used.Methyl 3-methylbenzoate (cas: 99-36-5) were involved in the experimental procedure.

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Electric Literature of C9H10O2 Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Formula: C19H36O2In 2022, Maidana Serpa, John Dayvan;Cavalieri de Alencar Guimaraes, Nelciele;Kioshi Yonekawa, Murilo Aquino;Pereira de Almeida, Aline;Ruller, Roberto;Augusto dos Santos Jaques, Jeandre;Santos, Edson dos Anjos dos;Masui, Douglas Chodi;Zanoelo, Fabiana Fonseca;Giannesi, Giovana Cristina published 《Sarocladium strictum lipase (LipSs) produced using crude glycerol as sole carbon source: A promising enzyme for biodiesel production》. 《Biocatalysis and Agricultural Biotechnology》published the findings. The article contains the following contents:

The production of biodiesel (fatty acid Me esters), an environmentally safe next-generation biofuel, using a lipase from Sarocladium strictum and glycerol (a biodiesel byproduct) as sole carbon source, was investigated. The fungus S. strictum showed maximum lipase production when grown in crude glycerol (3.13 U/mg protein) with 168 h of growth. Different concentrations of crude glycerol as carbon source were tested and concentrations ranging from 0.5 to 4% were completely consumed (100%) by the S. strictum. The lipase from S. strictum was purified (24.4-fold) with a specific activity of 73.2 U/mg protein showing a mol. weight of 52 kDa. The effects of pH and temperature in the lipase activity were evaluated showing optimal activity at pH 5.0 and 40°C, resp. Lipase hydrolyzed different substrates and exhibited better activity on p-nitrophenyl octanoate (30.68 U/mg protein). The detergents Triton X-100 and Tween 80 at concentration of 0.1% (volume/volume) increased the lipase activity by 10.45 and 8.55%, resp. The lipase maintained 80% residual activity in the presence of methanol (1:1, volume/volume) after 24 h of incubation. In concentrations ranging from 1 to 5% of methanol, showed activity above 90%, maintaining 70% activity at 10% concentration Gas chromatog. mass spectrometry (GC-MS) anal. confirmed biodiesel production with soybean and sunflower oil by lipase with a conversion rate of approx. 65 and 85%, resp. Therefore, the lipase was efficient in the conversion of low-cost plant oil to high-value biodiesel.Methyl oleate (cas: 112-62-9) were involved in the experimental procedure.

Methyl oleate(cas: 112-62-9) is an intermediate for detergents, emulsifiers, wetting agents, stabilizers, textile treatments, plasticizers for duplicating inks, rubbers, waxes etc.Formula: C19H36O2 It is also used in biochemical research as a chromatographic reference standard.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 106-02-5In 2019, Gong, Yi-hong;Shu, Man;Xie, Jian-hua;Zhang, Chao;Cao, Zhong;Jiang, Zhao-zhong;Liu, Jie published 《Enzymatic synthesis of PEG-poly(amine-co-thioether esters) as highly efficient pH and ROS dual-responsive nanocarriers for anticancer drug delivery》. 《Journal of Materials Chemistry B: Materials for Biology and Medicine》published the findings. The article contains the following contents:

Novel multifunctional drug nanocarriers have been successfully fabricated from a new type of enzymically synthesized, biodegradable block copolymer, PEG-poly(ω-pentadecalactone-co-N-methyldiethyleneamine-co-3,3′-thiodipropionate) (PEG-PPMT), which was responsive to tumor-relevant acidic pH (5.0-6.5) and intracellular reactive oxygen species (ROS) of tumor cells. The PEG-PPMT copolymers could self-assemble to form nano-scaled particles in aqueous solutions, which are stable in physiol. solutions, but swell substantially upon reducing the pH from 7.4 to 5.0 and/or in the presence of ROS on account of the protonation of the tertiary amino groups and oxidation of the thioether groups, causing a hydrophobic to hydrophilic transition in the nanoparticle cores. Consistently, docetaxel (DTX) encapsulated in PEG-PPMT nanoparticles can be triggered in a synergistic manner by acidic pH and a high-ROS environment in tumor cells to release the hydrophobic drug at accelerated rates for efficient tumor growth inhibition. In particular, DTX encapsulated in PEG-PPMT-11% PDL and PEG-PPMT-28% PDL nanoparticles exhibit extraordinarily enhanced potency (95% and 93% tumor-inhibiting efficiency, resp.) in inhibiting the growth of ROS-rich CT-26 tumors xenografted in mice. Importantly, biosafety analyses show minimal toxicity of DTX-loaded PEG-PPMT nanoparticles toward normal organs including liver and kidneys during the in vivo antitumor treatments. These results demonstrate that the PEG-PPMT nanoparticles are promising pH and ROS dual-responsive multifunctional nanocarriers for tumor site specific, controlled release of anticancer drugs to treat ROS-rich tumors.Oxacyclohexadecan-2-one (cas: 106-02-5) were involved in the experimental procedure.

Oxacyclohexadecan-2-one(cas:106-02-5) is a natural product found in Lonicera japonica and Angelica archangelica.Product Details of 106-02-5 It is a macrocyclic lactone that can be used as a flavoring agent and fragrance ingredient due to its musk flavor/odor.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application In Synthesis of 1-Phenylethyl acetate《Selective benzylic C-H monooxygenation mediated by iodine oxides》 was published in 2019. The authors were LaMartina, Kelsey B.;Kuck, Haley K.;Oglesbee, Linda S.;Odaini, Asma Al;Boaz, Nicholas C., and the article was included in《Beilstein Journal of Organic Chemistry》. The author mentioned the following in the article:

A method for the selective monooxdiation of secondary benzylic C-H bonds is described using an N-oxyl catalyst and a hypervalent iodine species as a terminal oxidant. Combinations of ammonium iodate and catalytic N-hydroxyphthalimide (NHPI) were shown to be effective in the selective oxidation of n-butylbenzene directly to 1-phenylbutyl acetate in high yield (86%). This method shows moderate substrate tolerance in the oxygenation of substrates containing secondary benzylic C-H bonds, yielding the corresponding benzylic acetates in good to moderate yield. Tertiary benzylic C-H bonds were shown to be unreactive under similar conditions, despite the weaker C-H bond. A preliminary mechanistic anal. suggests that this NHPI-iodate system is functioning by a radical-based mechanism where iodine generated in situ captures formed benzylic radicals. The benzylic iodide intermediate then solvolyzes to yield the product ester. The experimental procedure involved many compounds, such as 1-Phenylethyl acetate (cas: 93-92-5) .

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Application In Synthesis of 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from 1-bromoethylbenzene and silver acetate in acetic acid; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics