Peixoto, Philippe A.;Boulange, Agathe;Ball, Malcolm;Naudin, Bertrand;Alle, Thibault;Cosette, Pascal;Karuso, Peter;Franck, Xavier published 《Design and Synthesis of Epicocconone Analogues with Improved Fluorescence Properties》. The research results were published in《Journal of the American Chemical Society》 in 2014.Recommanded Product: 4707-47-5 The article conveys some information:
Epicocconone is a natural latent fluorophore that is widely used in biotechnol. because of its large Stokes shift and lack of fluorescence in its unconjugated state. However, the low photostability and quantum yields of epicocconone have limited its wider use, and in the absence of a total synthesis, this limitation was a long-standing problem. Here the authors report a general strategy for the synthesis of epicocconone analogs that relies on a 2-iodoxybenzoic acid-mediated dearomatization and on the replacement of the triene tail of the natural product by an aromatic ring. This design element is general and the synthesis is straightforward, providing ready access to libraries of polyfunctional fluorophores with long Stokes shifts based on the epicocconone core. The structural modifications resulted in analogs with increased photostability and quantum yields compared with the natural product. Staining proteomic gels with these new analogs showed significant lowering of the detection limit and a 30% increase in the number of low-abundance proteins detected. These epiccoconone analogs will substantially improve the discovery rate of biomarker needles in the proteomic haystack. And Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) was used in the research process.
Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Recommanded Product: 4707-47-5
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