Quality Control of Oxacyclohexadecan-2-one《Highly selective macrocyclic ring-closing metathesis of terminal olefins in non-chlorinated solvents at low dilution》 was published in 2019. The authors were Dumas, Adrien;Colombel-Rouen, Sophie;Curbet, Idriss;Forcher, Gwenael;Tripoteau, Fabien;Caijo, Frederic;Queval, Pierre;Rouen, Mathieu;Basle, Olivier;Mauduit, Marc, and the article was included in《Catalysis Science & Technology》. The author mentioned the following in the article:
Bis(cycloalkylarylimidazolylidene)ruthenium indenylidene complexes were prepared as catalysts for ring-closing metatheses of dienes to yield macrocycles, particularly macrocyclic lactone odorants, without isomerization and without using chlorinated solvents. Ring-closing metatheses were performed in EtOAc at 0.01 M substrate concentrations without requiring 1,4-benzoquinone to suppress isomerization. Macrocyclic odorant mols. were prepared in >99% purities by this method. And Oxacyclohexadecan-2-one (cas: 106-02-5) was used in the research process.
Oxacyclohexadecan-2-one(cas:106-02-5) is a monomer used to make PGA-co-pentadecalactone polymers to be used in the development of directly compressed prolonged release tablets of slightly soluble drugs such as ketoprofen.Quality Control of Oxacyclohexadecan-2-oneIt may be used for the synthesis of poly(pentadecanolide) (PPDL) by Novozyme 435 catalyzed ring-opening polymerization.
Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics