Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate. as in the substitution reaction of a carboxylic acid and an alcohol. Name: Di-tert-butyl diazene-1,2-dicarboxylate.
Jalaja, Renjitha;Leela, Shyni G.;Mohan, Sangeetha;Nair, Mangalam S.;Gopalan, Raghu K.;Somappa, Sasidhar B. research published 《 Anti-hyperlipidemic potential of natural product based labdane-pyrroles via inhibition of cholesterol and triglycerides synthesis》, the research content is summarized as follows. Hyperlipidemia is the clin. condition where blood has an increased level of lipids, such as cholesterol and triglycerides. Therefore controlling hyperlipidemia is considered to be a protective strategy to treat many associated diseases. Thus, a novel natural product-derived pyrrole and pyrazole (E)-labda-8(17),12-diene-15,16-dial conjugates possessing inhibition potential for cholesterol and triglyceride synthesis were designed through scaffold hopping approach and synthesized via one-pot selective cycloaddition Amongst the tested hybrids, 3i (I) exhibited excellent activity against triglyceride and cholesterol synthesis with the percentage inhibition of 71.73 ± 0.78 and 68.61 ± 1.19, which is comparable to the pos. controls fenofibrate and atorvastatin, resp. Compounds 3j and 3k (II and III, resp.) also exhibited the considerable potential of promising leads. The HMG CoA reductase inhibitory activity of the compounds was consistent with that of inhibitory activity of cholesterol synthesis. Compound 3i showed the highest inhibitory potential (78.61 ± 2.80) percentage of suppression, which was comparable to that of the pos. control pravastatin (78.05 ± 5.4). Favorably, none of the compounds showed cytotoxicity (HepG2) in the concentration ranging from 0.5 to 100μM.
870-50-8, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., Name: Di-tert-butyl diazene-1,2-dicarboxylate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics